IspG: Difference between revisions

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== Structural highlights ==
== Structural highlights ==


The substrate <scene name='77/774679/Cv/2'>MEcPP is located in the cavity between the TIM-barrel and the lid domain</scene> of IpsG.  <scene name='77/774679/Cv/3'>It binds covalently to the 4Fe4S cluster</scene> and its <scene name='77/774679/Cv/8'>PP moiety binds to 4 Arg and 1 Lys sidechains</scene><ref>PMID:22967895</ref>.
The substrate <scene name='77/774679/Cv/2'>MEcPP is located in the cavity between the TIM-barrel and the lid domain</scene> of IpsG.  <scene name='77/774679/Cv/3'>It binds covalently to the 4Fe4S cluster</scene> and its <scene name='77/774679/Cv/8'>PP moiety binds to 4 Arg and 1 Lys sidechains</scene>.
*<scene name='77/774679/Cv/6'>4Fe4S cluster binding site</scene>.
*<scene name='77/774679/Cv/6'>4Fe4S cluster binding site</scene>.
*<scene name='77/774679/Cv/7'>Whole active site</scene>.
*<scene name='77/774679/Cv/7'>Whole active site</scene>.
*<scene name='77/774679/Cv/9'>1st Cl coordination site</scene>.
*<scene name='77/774679/Cv/10'>Cl/K cluster coordination site</scene>.
</StructureSection>
</StructureSection>
== 3D Structures of IspG ==
== 3D Structures of IspG ==

Revision as of 13:15, 30 November 2017

IspG containing 4Fe4S cluster complex with MEcPP, MES, K+ (purple) and Cl- (green) ions (PDB entry 4g9p)

Drag the structure with the mouse to rotate

3D Structures of IspG

Updated on 30-November-2017

3noy – IspG – Aquifex aeolicus
4mwa – IspG – Bacillus anthracis
2y0f – TtIspG – Thermus thermophilus
4s38, 4g9p – TtIspG + MEcPP
4s39, 4s23 – TtIspG + HMBPP
4s3a, 4s3b, 4s3c – TtIspG + intermediate
4s3c – TtIspG + PPi
4s3e, 4s3f – TtIspG + inhibitor

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman