Terminase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 4: | Line 4: | ||
== Function == | == Function == | ||
'''Terminase''' (Ter) is a key component of the DNA packaging machine found in bacteriophages and herpesviruses. The Ter complex is comprised of a small Ter which is a recognition subunit and a large Ter which is an endonuclease/translocase subunit <ref>PMID:22297528</ref>. | '''Terminase''' (Ter) is a key component of the DNA packaging machine found in bacteriophages and herpesviruses. The Ter complex is comprised of a small Ter subunit which is a recognition subunit and a large Ter subunit which is an endonuclease/translocase subunit <ref>PMID:22297528</ref>. The nuclease activity of the large Ter subunit is stimulated by ATP. | ||
== Structural highlights == | == Structural highlights == | ||
The large subunit of Ter is composed of an N-terminal ATPase domain, a linker region and a C-terminal nuclease domain. ATP binds to the protein in a groove between the ATPase domain and the linker region<ref>PMID:23630261</ref>. | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of terminase == | == 3D Structures of terminase == | ||
