5trl: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5trl is ~~ON HOLD until Dec 27 2018~~

==Crystal structure of human GCN5 histone acetyltransferase domain==

~~Authors~~: ~~Guo~~, Y.R., ~~Tao~~, Y.J.

== Structural highlights ==

<table><tr><td colspan='2'>[[5trl]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TRL OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TRL FirstGlance].

~~Description~~: ~~Crystal structure~~ of ~~human GCN5~~ histone acetyltransferase ~~domain~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=SCA:SUCCINYL-COENZYME+A'>SCA</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5trm|5trm]]</td></tr>

[[Category: Guo, Y.R]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </td></tr>

[[Category: Tao, Y.J]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5trl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5trl OCA], [http://pdbe.org/5trl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5trl RCSB], [http://www.ebi.ac.uk/pdbsum/5trl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5trl ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/KAT2A_HUMAN KAT2A_HUMAN]] Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.<ref>PMID:17301242</ref> <ref>PMID:19103755</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Histone acetyltransferase]]

[[Category: Guo, Y R]]

[[Category: Tao, Y J]]

[[Category: Apo]]

[[Category: Transferase]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5trl is ON HOLD  until Dec 27 2018
+==Crystal structure of human GCN5 histone acetyltransferase domain==
+<StructureSection load='5trl' size='340' side='right' caption='[[5trl]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-Authors: Guo, Y.R., Tao, Y.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5trl]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TRL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TRL FirstGlance]. <br>
-Description: Crystal structure of human GCN5 histone acetyltransferase domain
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCA:SUCCINYL-COENZYME+A'>SCA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5trm|5trm]]</td></tr>
-[[Category: Guo, Y.R]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
-[[Category: Tao, Y.J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5trl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5trl OCA], [http://pdbe.org/5trl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5trl RCSB], [http://www.ebi.ac.uk/pdbsum/5trl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5trl ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KAT2A_HUMAN KAT2A_HUMAN]] Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.<ref>PMID:17301242</ref> <ref>PMID:19103755</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Histone acetyltransferase]]
+[[Category: Guo, Y R]]
+[[Category: Tao, Y J]]
+[[Category: Apo]]
+[[Category: Transferase]]