5xk1: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5xk1 is ~~ON HOLD~~

==Structure of 8-mer DNA3==

== Structural highlights ==

<table><tr><td colspan='2'>[[5xk1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XK1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XK1 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xk1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xk1 OCA], [http://pdbe.org/5xk1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xk1 RCSB], [http://www.ebi.ac.uk/pdbsum/5xk1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xk1 ProSAT]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Metal-mediated base pairs have been extensively utilized in many research fields, including genetic-code extension, novel therapeutics development, and nanodevice design. Compared to other cations, Ag(I) is more flexible in pairing with natural base pairs. Herein, we present a DNA structure containing two C-Ag(I) -C pairs and the first reported G-Ag(I) -G pair in a short 8mer DNA strand. This structure not only provides detailed insight into these Ag(I) -mediated base-pairing patterns in DNA, but also represents the first nonhelical DNA structure driven by heavy-metal ions, thus further contributing to the structural diversity of DNA. This unique complex structure is highly sequence-dependent, thus implying functional potentials as a new DNA aptamer that can bind and recognize silver ions. These results not only advance our understanding of the interactions between Ag(I) and nucleobases, but also provide a unique structural component for the rational design of new DNA nanodevices.

~~Authors~~:

A DNA Structure Containing Ag(I) -Mediated G:G and C:C Base Pairs.,Liu H, Shen F, Haruehanroengra P, Yao Q, Cheng Y, Chen Y, Yang C, Zhang J, Wu B, Luo Q, Cui R, Li J, Ma J, Sheng J, Gan J Angew Chem Int Ed Engl. 2017 Aug 1;56(32):9430-9434. doi: 10.1002/anie.201704891., Epub 2017 Jul 7. PMID:28635152<ref>PMID:28635152</ref>

~~Description~~:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

[[Category: ~~Unreleased Structures~~]]

</div>

== References ==

__TOC__

</StructureSection>

[[Category: Gan, J H]]

[[Category: Liu, H H]]

[[Category: Dna]]

[[Category: Duplex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5xk1 is ON HOLD
+==Structure of 8-mer DNA3==
+<StructureSection load='5xk1' size='340' side='right' caption='[[5xk1]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5xk1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XK1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XK1 FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xk1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xk1 OCA], [http://pdbe.org/5xk1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xk1 RCSB], [http://www.ebi.ac.uk/pdbsum/5xk1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xk1 ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Metal-mediated base pairs have been extensively utilized in many research fields, including genetic-code extension, novel therapeutics development, and nanodevice design. Compared to other cations, Ag(I) is more flexible in pairing with natural base pairs. Herein, we present a DNA structure containing two C-Ag(I) -C pairs and the first reported G-Ag(I) -G pair in a short 8mer DNA strand. This structure not only provides detailed insight into these Ag(I) -mediated base-pairing patterns in DNA, but also represents the first nonhelical DNA structure driven by heavy-metal ions, thus further contributing to the structural diversity of DNA. This unique complex structure is highly sequence-dependent, thus implying functional potentials as a new DNA aptamer that can bind and recognize silver ions. These results not only advance our understanding of the interactions between Ag(I) and nucleobases, but also provide a unique structural component for the rational design of new DNA nanodevices.
-Authors:
+A DNA Structure Containing Ag(I) -Mediated G:G and C:C Base Pairs.,Liu H, Shen F, Haruehanroengra P, Yao Q, Cheng Y, Chen Y, Yang C, Zhang J, Wu B, Luo Q, Cui R, Li J, Ma J, Sheng J, Gan J Angew Chem Int Ed Engl. 2017 Aug 1;56(32):9430-9434. doi: 10.1002/anie.201704891., Epub 2017 Jul 7. PMID:28635152<ref>PMID:28635152</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 5xk1" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Gan, J H]]
+[[Category: Liu, H H]]
+[[Category: Dna]]
+[[Category: Duplex]]