User:Harish Srinivas: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 9: | Line 9: | ||
==''Transmembrane region''== | ==''Transmembrane region''== | ||
One cluster of core contacts links transmembrane '''(TM) I, II, and VII, cluster 1''' consists of individual interaction groups. '''The second cluster''' of interactions links '''TM II, III, and IV''' through a series of four interaction groups and a frequently observed interaction between position interact through a hydrogen bond between an Asn or Ser and the indole nitrogen of a Trp. '''A third cluster''' of conserved contacts links together TM helices III, VI, and VII in the vicinity of the S1P1 receptor ligand binding pocket. These positions maintain important contacts between '''TM VI and TM III''' through two side chain-mediated interactions. Finally, '''cluster number four''' consists of three interactions that constrain '''TM V relative to TM III and one interaction between TM V and TM VI(4). | One cluster of core contacts links transmembrane '''(TM) I, II, and VII, cluster 1''' consists of individual interaction groups. '''The second cluster''' of interactions links '''TM II, III, and IV''' through a series of four interaction groups and a frequently observed interaction between position interact through a hydrogen bond between an Asn or Ser and the indole nitrogen of a Trp. '''A third cluster''' of conserved contacts links together TM helices III, VI, and VII in the vicinity of the S1P1 receptor ligand binding pocket. These positions maintain important contacts between '''TM VI and TM III''' through two side chain-mediated interactions. Finally, '''cluster number four''' consists of three interactions that constrain '''TM V relative to TM III and one interaction between TM V and TM VI'''(4). | ||
==''Exrtra-cellular region''== | ==''Exrtra-cellular region''== | ||
