5uph: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5uph is ~~ON HOLD until Paper Publication~~

==Lipids bound lysosomal integral membrane protein 2==

~~Authors~~: ~~Conrad~~, K.S., ~~Liu~~, S.

== Structural highlights ==

<table><tr><td colspan='2'>[[5uph]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UPH FirstGlance]. <br>

~~Description~~: ~~Lipids bound lysosomal integral membrane protein 2~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=M6D:6-O-PHOSPHONO-BETA-D-MANNOPYRANOSE'>M6D</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCW:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PCW</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uph OCA], [http://pdbe.org/5uph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uph RCSB], [http://www.ebi.ac.uk/pdbsum/5uph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uph ProSAT]</span></td></tr>

[[Category: Conrad, K.S]]

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/SCRB2_HUMAN SCRB2_HUMAN]] Unverricht-Lundborg disease;Gaucher disease type 1;Action myoclonus - renal failure syndrome. The disease is caused by mutations affecting the gene represented in this entry. Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease.

== Function ==

[[http://www.uniprot.org/uniprot/SCRB2_HUMAN SCRB2_HUMAN]] Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.<ref>PMID:18022370</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Conrad, K S]]

[[Category: Liu, S]]

[[Category: Lysosomal integral membrane protein 2]]

[[Category: Membrane protein]]

[[Category: Phospholipid receptor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5uph is ON HOLD  until Paper Publication
+==Lipids bound lysosomal integral membrane protein 2==
+<StructureSection load='5uph' size='340' side='right' caption='[[5uph]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-Authors: Conrad, K.S., Liu, S.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5uph]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UPH FirstGlance]. <br>
-Description: Lipids bound lysosomal integral membrane protein 2
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=M6D:6-O-PHOSPHONO-BETA-D-MANNOPYRANOSE'>M6D</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCW:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PCW</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uph OCA], [http://pdbe.org/5uph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uph RCSB], [http://www.ebi.ac.uk/pdbsum/5uph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uph ProSAT]</span></td></tr>
-[[Category: Conrad, K.S]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/SCRB2_HUMAN SCRB2_HUMAN]] Unverricht-Lundborg disease;Gaucher disease type 1;Action myoclonus - renal failure syndrome. The disease is caused by mutations affecting the gene represented in this entry.  Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease.
+== Function ==
+[[http://www.uniprot.org/uniprot/SCRB2_HUMAN SCRB2_HUMAN]] Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.<ref>PMID:18022370</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Conrad, K S]]
 [[Category: Liu, S]]
+[[Category: Lysosomal integral membrane protein 2]]
+[[Category: Membrane protein]]
+[[Category: Phospholipid receptor]]