VprBP: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''VPRBP''' (VPR-binding protein) is a HIV-1 WD40 protein is essentia... |
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<StructureSection load='5jk7' size='340' side='right' caption='Human VprBP residues 1045-1396 (pink) complex with Vpr (cyan), DNA damage-binding protein (grey) and uracil-DNA glycosylase (yellow) (PDB code [[5jk7]]' scene=''> | |||
<StructureSection load=' | |||
== Function == | == Function == | ||
''' | '''VprBP''' (VPR-binding protein) is a HIV-1 WD40 protein is essential for DNA replication and embryonic development<ref>PMID:18606781</ref>. VprBP has intrinsic kinase activity and is capable of phosphorylating histone H2A. Recruitment of VprBP by Vpr is essential for HIV-1 VPR activity of initiating the host cell response cycle arresting its G(2) phase following mitosis<ref>PMID:17314515</ref>. VprBP interacts with merlin which is then recruited to the E3 ligase complex resulting in its polyubiquitination and consequently its proteasome-mediated degradation<ref>PMID:18332868</ref>. | ||
== Relevance == | == Relevance == | ||
VprBP inhibition could be a strategy for the development of anticancer therapeutics<ref>PMID:24140421</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[4pxw]] – | [[4pxw]] – hVprBP residues 1039-1401 (mutant) - human <br /> | ||
[[3wa0]] – | [[3wa0]] – hVprBP residues 1417-1506 + merlin <br /> | ||
[[4p7i]] – | [[4p7i]] – hVprBP residues 998-1058 + merlin <br /> | ||
[[4z8l]], [[5aja]], [[4cc9]] – | [[4z8l]], [[5aja]], [[4cc9]] – hVprBP residues 1057-1396 + VPX + SAMHD1 <br /> | ||
[[5jk7]] – | [[5jk7]] – hVprBP residues 1045-1396 + Vpr + DNA damage-binding protein + uracil-DNA glycosylase <br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
