5ytk: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5ytk is ~~ON HOLD until Paper Publication~~

==Crystal structure of SIRT3 bound to a leucylated AceCS2==

~~Authors~~: Li, J., ~~Gong~~, W., Xu, Y.

== Structural highlights ==

<table><tr><td colspan='2'>[[5ytk]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YTK FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of ~~SIRT3 bound to a leucylated AceCS2~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ytk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ytk OCA], [http://pdbe.org/5ytk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ytk RCSB], [http://www.ebi.ac.uk/pdbsum/5ytk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ytk ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN]] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Gong, W]]

[[Category: Li, J]]

~~[[Category: Gong, W]]~~

[[Category: Xu, Y]]

[[Category: Dna-dependent deacetylase sirtuin-3]]

[[Category: Hydrolase]]

[[Category: Leucylated acecs2]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ytk is ON HOLD  until Paper Publication
+==Crystal structure of SIRT3 bound to a leucylated AceCS2==
+<StructureSection load='5ytk' size='340' side='right' caption='[[5ytk]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-Authors: Li, J., Gong, W., Xu, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ytk]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YTK FirstGlance]. <br>
-Description: Crystal structure of SIRT3 bound to a leucylated AceCS2
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ytk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ytk OCA], [http://pdbe.org/5ytk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ytk RCSB], [http://www.ebi.ac.uk/pdbsum/5ytk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ytk ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN]] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Gong, W]]
 [[Category: Li, J]]
-[[Category: Gong, W]]
 [[Category: Xu, Y]]
+[[Category: Dna-dependent deacetylase sirtuin-3]]
+[[Category: Hydrolase]]
+[[Category: Leucylated acecs2]]