6b5v: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The ~~entry 6b5v~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Structure of TRPV5 in complex with econazole==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6b5v]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B5V FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ECL:1-[(2R)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE'>ECL</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b5v OCA], [http://pdbe.org/6b5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b5v RCSB], [http://www.ebi.ac.uk/pdbsum/6b5v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b5v ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/TRPV5_RABIT TRPV5_RABIT]] Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:12574114). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (By similarity). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (PubMed:12574114).[UniProtKB:P69744][UniProtKB:Q9NQA5]<ref>PMID:10085067</ref> <ref>PMID:11035011</ref> <ref>PMID:12574114</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Basak, S]]

[[Category: Chakrapani, S]]

[[Category: Filizola, M]]

[[Category: Han, S]]

[[Category: Hughes, T E.T]]

[[Category: Huynh, K W]]

[[Category: Kapoor, A]]

[[Category: Lodowski, D T]]

[[Category: Moiseenkova-Bell, V Y]]

[[Category: Rohacs, T]]

[[Category: Rosario, J del]]

[[Category: Samanta, A]]

[[Category: Yazici, A]]

[[Category: Zhou, Z H]]

[[Category: Cryo-em]]

[[Category: Econazole]]

[[Category: Membrane protein]]

[[Category: Transient receptor potential channel]]

[[Category: Trpv5]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6b5v is ON HOLD  until Paper Publication
+==Structure of TRPV5 in complex with econazole==
+<StructureSection load='6b5v' size='340' side='right' caption='[[6b5v]], [[Resolution|resolution]] 4.80&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6b5v]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B5V FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ECL:1-[(2R)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE'>ECL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b5v OCA], [http://pdbe.org/6b5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b5v RCSB], [http://www.ebi.ac.uk/pdbsum/6b5v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b5v ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TRPV5_RABIT TRPV5_RABIT]] Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:12574114). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (By similarity). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (PubMed:12574114).[UniProtKB:P69744][UniProtKB:Q9NQA5]<ref>PMID:10085067</ref> <ref>PMID:11035011</ref> <ref>PMID:12574114</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Basak, S]]
+[[Category: Chakrapani, S]]
+[[Category: Filizola, M]]
+[[Category: Han, S]]
+[[Category: Hughes, T E.T]]
+[[Category: Huynh, K W]]
+[[Category: Kapoor, A]]
+[[Category: Lodowski, D T]]
+[[Category: Moiseenkova-Bell, V Y]]
+[[Category: Rohacs, T]]
+[[Category: Rosario, J del]]
+[[Category: Samanta, A]]
+[[Category: Yazici, A]]
+[[Category: Zhou, Z H]]
+[[Category: Cryo-em]]
+[[Category: Econazole]]
+[[Category: Membrane protein]]
+[[Category: Transient receptor potential channel]]
+[[Category: Trpv5]]