6bw3: Difference between revisions

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'''Unreleased structure'''


The entry 6bw3 is ON HOLD
==Crystal structure of RBBP4 in complex with PRDM3 N-terminal peptide==
 
<StructureSection load='6bw3' size='340' side='right' caption='[[6bw3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
Authors: Ivanochko, D., Halabelian, L., Hutchinson, A., Seitova, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6bw3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BW3 FirstGlance]. <br>
Description: Crystal structure of RBBP4 in complex with PRDM3 N-terminal peptide.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bw3 OCA], [http://pdbe.org/6bw3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bw3 RCSB], [http://www.ebi.ac.uk/pdbsum/6bw3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bw3 ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/MDS1_HUMAN MDS1_HUMAN]] A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML). Translocation t(3;21) with AML1.<ref>PMID:8643684</ref> 
== Function ==
[[http://www.uniprot.org/uniprot/RBBP4_HUMAN RBBP4_HUMAN]] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Edwards, A M]]
[[Category: Halabelian, L]]
[[Category: Hutchinson, A]]
[[Category: Hutchinson, A]]
[[Category: Arrowsmith, C.H]]
[[Category: Ivanochko, D]]
[[Category: Structural genomic]]
[[Category: Seitova, A]]
[[Category: Seitova, A]]
[[Category: Halabelian, L]]
[[Category: Chromatin regulator]]
[[Category: Structural Genomics Consortium, Structural Genomics Consortium (Sgc)]]
[[Category: Complex]]
[[Category: Ivanochko, D]]
[[Category: Epigenetic]]
[[Category: Edwards, A.M]]
[[Category: Gene regulation]]
[[Category: Bountra, C]]
[[Category: Histone-binding protein]]
[[Category: Nucleus]]
[[Category: Nurd]]
[[Category: Repressor]]
[[Category: Sgc]]
[[Category: Wd repeat]]
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