5w78: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5w78 is ~~ON HOLD~~ ~~until Paper Publication~~

==Human acyloxyacyl hydrolase (AOAH), proteolytically processed==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5w78]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W78 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W78 FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Acyloxyacyl_hydrolase Acyloxyacyl hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.77 3.1.1.77] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w78 OCA], [http://pdbe.org/5w78 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w78 RCSB], [http://www.ebi.ac.uk/pdbsum/5w78 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w78 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/AOAH_HUMAN AOAH_HUMAN]] Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (PubMed:1883828, PubMed:8089145). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity).[UniProtKB:O35298]<ref>PMID:1883828</ref> <ref>PMID:8089145</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Acyloxyacyl hydrolase]]

[[Category: Gorelik, A]]

[[Category: Illes, K]]

[[Category: Nagar, B]]

[[Category: Gdsl esterase]]

[[Category: Hydrolase]]

[[Category: Lipopolysaccharide]]

[[Category: Lp]]

[[Category: Saposin]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5w78 is ON HOLD  until Paper Publication
+==Human acyloxyacyl hydrolase (AOAH), proteolytically processed==
+<StructureSection load='5w78' size='340' side='right' caption='[[5w78]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5w78]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W78 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W78 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acyloxyacyl_hydrolase Acyloxyacyl hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.77 3.1.1.77] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w78 OCA], [http://pdbe.org/5w78 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w78 RCSB], [http://www.ebi.ac.uk/pdbsum/5w78 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w78 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/AOAH_HUMAN AOAH_HUMAN]] Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (PubMed:1883828, PubMed:8089145). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity).[UniProtKB:O35298]<ref>PMID:1883828</ref> <ref>PMID:8089145</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Acyloxyacyl hydrolase]]
+[[Category: Gorelik, A]]
+[[Category: Illes, K]]
+[[Category: Nagar, B]]
+[[Category: Gdsl esterase]]
+[[Category: Hydrolase]]
+[[Category: Lipopolysaccharide]]
+[[Category: Lp]]
+[[Category: Saposin]]