1gl4: Difference between revisions

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==~~NIDOGEN~~-1 G2/~~PERLECAN~~ IG3 ~~COMPLEX~~==

==Nidogen-1 G2/Perlecan IG3 Complex==

== Structural highlights ==

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</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[1h4u|1h4u]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gl4 OCA], [http://pdbe.org/1gl4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gl4 RCSB], [http://www.ebi.ac.uk/pdbsum/1gl4 PDBsum]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gl4 OCA], [http://pdbe.org/1gl4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gl4 RCSB], [http://www.ebi.ac.uk/pdbsum/1gl4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gl4 ProSAT]</td></tr>

</table>

~~== Function ==~~

[[http://www.uniprot.org/uniprot/PGBM_MOUSE PGBM_MOUSE]] Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development (By similarity).<ref>PMID:10545953</ref> <ref>PMID:18694874</ref> Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6 (By similarity).<ref>PMID:10545953</ref> <ref>PMID:18694874</ref> The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity (By similarity).<ref>PMID:10545953</ref> <ref>PMID:18694874</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

Check<jmol>

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gl/1gl4_consurf.spt"</scriptWhenChecked>

<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gl/1gl4_consurf.spt"</scriptWhenChecked>

<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>

<text>to colour the structure by Evolutionary Conservation</text>

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@@ Line 1: / Line 1: @@
-==NIDOGEN-1 G2/PERLECAN IG3 COMPLEX==
+==Nidogen-1 G2/Perlecan IG3 Complex==
 <StructureSection load='1gl4' size='340' side='right' caption='[[1gl4]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
@@ Line 5: / Line 6: @@
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1h4u|1h4u]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gl4 OCA], [http://pdbe.org/1gl4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gl4 RCSB], [http://www.ebi.ac.uk/pdbsum/1gl4 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gl4 OCA], [http://pdbe.org/1gl4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gl4 RCSB], [http://www.ebi.ac.uk/pdbsum/1gl4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gl4 ProSAT]</span></td></tr>
 </table>
-== Function ==
-[[http://www.uniprot.org/uniprot/PGBM_MOUSE PGBM_MOUSE]] Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development (By similarity).<ref>PMID:10545953</ref> <ref>PMID:18694874</ref>   Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6 (By similarity).<ref>PMID:10545953</ref> <ref>PMID:18694874</ref>   The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity (By similarity).<ref>PMID:10545953</ref> <ref>PMID:18694874</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gl/1gl4_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gl/1gl4_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>