5ms4: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5ms4 is ~~ON HOLD until Paper Publication~~

==Kallikrein-related peptidase 8 leupeptin inhibitor complex==

~~Authors~~: ~~Debela~~, M., ~~Magdolen~~, V., ~~Skala~~, W., ~~Bode~~, W., ~~Brandstetter~~, H., ~~Goettig, P~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5ms4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MS4 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MS4 FirstGlance].

~~Description~~: Kallikrein~~-related peptidase~~ 8 ~~leupeptin inhibitor complex~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SVC:N-acetyl-L-leucyl-N-[(2S)-5-carbamimidamido-1-hydroxypentan-2-yl]-L-leucinamide'>SVC</scene>, <scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Kallikrein_8 Kallikrein 8], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.118 3.4.21.118] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ms4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ms4 OCA], [http://pdbe.org/5ms4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ms4 RCSB], [http://www.ebi.ac.uk/pdbsum/5ms4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ms4 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/KLK8_HUMAN KLK8_HUMAN]] Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.<ref>PMID:16337200</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Kallikrein 8]]

[[Category: Bode, W]]

[[Category: Brandstetter, H]]

[[Category: Debela, M]]

[[Category: Goettig, P]]

[[Category: Magdolen, V]]

[[Category: Skala, W]]

[[Category: ~~Bode, W~~]]

[[Category: Aldehyde inhibitor]]

[[Category: ~~Magdolen, V~~]]

[[Category: Ca2+ complex]]

[[Category: ~~Goettig, P~~]]

[[Category: Hydrolase-inhibitor complex]]

[[Category: ~~Debela, M~~]]

[[Category: Synaptic remodeling]]

[[Category: Trypsin-like serine protease]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ms4 is ON HOLD  until Paper Publication
+==Kallikrein-related peptidase 8 leupeptin inhibitor complex==
+<StructureSection load='5ms4' size='340' side='right' caption='[[5ms4]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-Authors: Debela, M., Magdolen, V., Skala, W., Bode, W., Brandstetter, H., Goettig, P.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ms4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MS4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MS4 FirstGlance]. <br>
-Description: Kallikrein-related peptidase 8 leupeptin inhibitor complex
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SVC:N-acetyl-L-leucyl-N-[(2S)-5-carbamimidamido-1-hydroxypentan-2-yl]-L-leucinamide'>SVC</scene>, <scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kallikrein_8 Kallikrein 8], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.118 3.4.21.118] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ms4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ms4 OCA], [http://pdbe.org/5ms4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ms4 RCSB], [http://www.ebi.ac.uk/pdbsum/5ms4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ms4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KLK8_HUMAN KLK8_HUMAN]] Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.<ref>PMID:16337200</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Kallikrein 8]]
+[[Category: Bode, W]]
 [[Category: Brandstetter, H]]
+[[Category: Debela, M]]
+[[Category: Goettig, P]]
+[[Category: Magdolen, V]]
 [[Category: Skala, W]]
-[[Category: Bode, W]]
+[[Category: Aldehyde inhibitor]]
-[[Category: Magdolen, V]]
+[[Category: Ca2+ complex]]
-[[Category: Goettig, P]]
+[[Category: Hydrolase-inhibitor complex]]
-[[Category: Debela, M]]
+[[Category: Synaptic remodeling]]
+[[Category: Trypsin-like serine protease]]