6fae: Difference between revisions

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'''Unreleased structure'''


The entry 6fae is ON HOLD  until Paper Publication
==The Sec7 domain of IQSEC2 (Brag1) in complex with the small GTPase Arf1==
 
<StructureSection load='6fae' size='340' side='right' caption='[[6fae]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
Authors: Gray, J., Krojer, T., Fairhead, M., Bountra, C., Arrowsmith, C.H., Edwards, A., Brennan, P., von Delft, F.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6fae]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FAE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FAE FirstGlance]. <br>
Description: The Sec7 domain of IQSEC2 (Brag1) in complex with the small GTPase Arf1
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fae OCA], [http://pdbe.org/6fae PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fae RCSB], [http://www.ebi.ac.uk/pdbsum/6fae PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fae ProSAT]</span></td></tr>
[[Category: Arrowsmith, C.H]]
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/IQEC2_HUMAN IQEC2_HUMAN]] Severe intellectual disability-progressive postnatal microcephaly- midline stereotypic hand movements syndrome;X-linked non-syndromic intellectual disability. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[[http://www.uniprot.org/uniprot/IQEC2_HUMAN IQEC2_HUMAN]] Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins.<ref>PMID:26793055</ref>  [[http://www.uniprot.org/uniprot/ARF1_HUMAN ARF1_HUMAN]] GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Brennan, P]]
[[Category: Delft, F von]]
[[Category: Edwards, A]]
[[Category: Fairhead, M]]
[[Category: Gray, J]]
[[Category: Gray, J]]
[[Category: Fairhead, M]]
[[Category: Von Delft, F]]
[[Category: Edwards, A]]
[[Category: Krojer, T]]
[[Category: Krojer, T]]
[[Category: Brennan, P]]
[[Category: Gtpase gef]]
[[Category: Bountra, C]]
[[Category: Hydrolase]]
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