6b3y: Difference between revisions
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==Crystal structure of the PH-like domain from DENND3== | |||
<StructureSection load='6b3y' size='340' side='right' caption='[[6b3y]], [[Resolution|resolution]] 1.85Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6b3y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B3Y FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b3y OCA], [http://pdbe.org/6b3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b3y RCSB], [http://www.ebi.ac.uk/pdbsum/6b3y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b3y ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/DEND3_MOUSE DEND3_MOUSE]] Guanine nucleotide exchange factor (GEF) activating Rab12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab12 into its active GTP-bound form. Regulates autophagy in response to starvation through Rab12 activation (PubMed:24719330, PubMed:25925668, PubMed:28249939). Starvation leads to ULK1/2-dependent phosphorylation of Ser-554 and Ser-572, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards Rab12 (PubMed:25925668). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:21718402, PubMed:24719330). Starvation also induces phosphorylation at Tyr-940, which leads to up-regulated GEF activity and initiates autophagy (PubMed:28249939).<ref>PMID:21718402</ref> <ref>PMID:24719330</ref> <ref>PMID:25925668</ref> <ref>PMID:28249939</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Beaugrand, M]] | |||
[[Category: Gehring, K]] | |||
[[Category: Kozlov, G]] | |||
[[Category: McPherson, P S]] | |||
[[Category: Menade, M]] | |||
[[Category: Pan, T]] | |||
[[Category: Xu, J]] | |||
[[Category: Autophagy]] | |||
[[Category: Guanine nucleotide exchange factor]] | |||
[[Category: Ph-like fold]] | |||
[[Category: Transport protein]] | |||
Revision as of 18:29, 24 January 2018
Crystal structure of the PH-like domain from DENND3
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