6b58: Difference between revisions

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'''Unreleased structure'''


The entry 6b58 is ON HOLD  until Paper Publication
==FrdA-SdhE assembly intermediate==
 
<StructureSection load='6b58' size='340' side='right' caption='[[6b58]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
Authors: Sharma, P., Iverson, T.M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6b58]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B58 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B58 FirstGlance]. <br>
Description: FrdA-SdhE assembly intermediate
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PBF:PARA-(BENZOYL)-PHENYLALANINE'>PBF</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_reductase_(quinol) Fumarate reductase (quinol)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.4 1.3.5.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b58 OCA], [http://pdbe.org/6b58 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b58 RCSB], [http://www.ebi.ac.uk/pdbsum/6b58 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b58 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/FRDA_ECOLI FRDA_ECOLI]] Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. [[http://www.uniprot.org/uniprot/SDHE_ECO57 SDHE_ECO57]] An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.[UniProtKB:G4V4G2]
__TOC__
</StructureSection>
[[Category: Iverson, T M]]
[[Category: Sharma, P]]
[[Category: Sharma, P]]
[[Category: Iverson, T.M]]
[[Category: Assembly intermediate]]
[[Category: Complex]]
[[Category: Flavoprotein]]
[[Category: Frda]]
[[Category: Respiration]]
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