4faj

Structure and mode of peptide binding of pheromone receptor PrgZ

spinqualitylabelsall models 4faj, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4faj is a 2 chain structure with sequence from "enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GOL, ZN Gene: prgZ ("Enterococcus proteiformis" Thiercelin and Jouhaud 1903) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [CCF1_ENTFL] cCF10 is involved in the conjugative transfer of the hemolysin plasmid pCF10. Publication Abstract from PubMed We present the crystal structure of the pheromone receptor protein PrgZ from Enterococcus faecalis in complex with the heptapeptide cCF10 (LVTLVFV), which is used in signaling between conjugative recipient and donor cells. Comparison of PrgZ with homologous oligopeptide-binding proteins (AppA and OppA) explains the high specificity of PrgZ for hydrophobic heptapeptides versus the promiscuity of peptide binding in the homologous proteins. Structure and Mode of Peptide Binding of Pheromone Receptor PrgZ.,Berntsson RP, Schuurman-Wolters GK, Dunny G, Slotboom DJ, Poolman B J Biol Chem. 2012 Oct 26;287(44):37165-70. doi: 10.1074/jbc.M112.386334. Epub, 2012 Sep 4. PMID:22948145 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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