Sandbox Reserved 1440: Difference between revisions
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== 5T4B == | == 5T4B == | ||
5T4B has a resolution of 1.76 Å and can be seen here with the 75N ligand within the binding pocket. There are more RSRZ outliers near the entrance to the binding cavity, but few clashes near the actual binding site. This indicates that the binding pocket itself has validity, but the mechanism for the ligand entering the cavity may be in question. | |||
<jmol><jmollink><text>View Figure 1c: 1NU6</text><script>exit;figure=1;SCRIPT "http://proteopedia.org/wiki/images/a/a4/5t4b_A.png";spin on</script></jmollink></jmol> | |||
Shown in Figure 1c is a view of a the 75N ligand inside the binding pocket of DPP-4. | |||
The 5T4B catalytic triad shown with electron density around the SER630, HIS740 and ASP706 residuals. There are no clashes at the triad. | |||
To see the binding pocket of the 75N ligand at the catalytic triad, click on Figure 1d. There is electron density from the catalytic triad that extends into the binding pocket, and surrounding the functional binding groups on the ligand. No RSRZ outliers are found within the binding pocket, and this conformation of the molecule is supported by the electron density surrounding the catalytic triad. | |||
<jmol><jmollink><text>View Figure 1d: 1NU6</text><script>exit;figure=1;SCRIPT "http://proteopedia.org/wiki/images/a/a4/5t4b_A.png";zoomto *5</script></jmollink></jmol> | |||
== 6B1E == | == 6B1E == | ||
