Sandbox Reserved 1431: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
No edit summary
Line 1: Line 1:
==Crystal structure of the µ-opioid receptor bound to a morphinan antagonist==
==Crystal structure of the µ-opioid receptor bound to a morphinan antagonist==
Please note this way for '''referencing a paper''' using the PubmedID <ref>pmid 22437502</ref>. The full reference appears at the bottom of the page.


[https://www.nature.com/articles/nature10954 Nature volume 485, pages 321–326 (17 May 2012)
[https://www.nature.com/articles/nature10954 Nature volume 485, pages 321–326 (17 May 2012)
Line 14: Line 12:
Notice that the inhibitor, shown as space-filling spheres, is nestled relatively deeply within the helical core. Binding at this position effects a change in conformation through a twisting action of the helices. This twisting gets delivered to a second binding site of the receptor. This second binding site is attached to the helical assembly via TM3 and TM6 (not shown here). It is where an associated protein that binds GTP can bind. This protein's binding is what makes this receptor a "G-protein-coupled receptor." Its binding triggers the transmission of the chemical "signal" delivered by the opioid (or, in this case, being prevented from doing that).   
Notice that the inhibitor, shown as space-filling spheres, is nestled relatively deeply within the helical core. Binding at this position effects a change in conformation through a twisting action of the helices. This twisting gets delivered to a second binding site of the receptor. This second binding site is attached to the helical assembly via TM3 and TM6 (not shown here). It is where an associated protein that binds GTP can bind. This protein's binding is what makes this receptor a "G-protein-coupled receptor." Its binding triggers the transmission of the chemical "signal" delivered by the opioid (or, in this case, being prevented from doing that).   


Investigate the structure by dragging it around using your mouse or clicking the buttons below. Press SHIFT to zoom.
Investigate the structure after downloading the <jmol><jmollink><text>figure</text><script>exit;SCRIPT "http://proteopedia.org/wiki/images/2/20/Nature10954Fig1aLeft_4dkl-2.png"</script></jmollink></jmol> by dragging it around using your mouse or clicking the buttons below. SHIFT-drag to zoom.
   
   
<jmol><jmollink><text>(a) exocellular view</text><script>SCRIPT http://proteopedia.org/wiki/images/0/00/Nature10954_fig1d.spt('top')</script></jmollink></jmol>
<jmol><jmollink><text>(a) exocellular view</text><script>SCRIPT http://proteopedia.org/wiki/images/0/00/Nature10954_fig1d.spt('top')</script></jmollink></jmol>
Retrieved from "https://proteopedia.org/Sandbox_Reserved_1431"