5upp: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5upp is ~~ON HOLD until Paper Publication~~

==Crystal structure of human fumarate hydratase==

~~Authors~~: ~~Rangel~~, V.L., ~~Ajalla~~, M.A., ~~Rustiguel~~, J.K., ~~Pereira de Padua~~, R.A.~~, Nonato, M~~.C.

== Structural highlights ==

<table><tr><td colspan='2'>[[5upp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UPP OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UPP FirstGlance].

~~Description~~: ~~Crystal structure of human fumarate~~ hydratase

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </td></tr>

[[Category: Rangel, V.L]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5upp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5upp OCA], [http://pdbe.org/5upp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5upp RCSB], [http://www.ebi.ac.uk/pdbsum/5upp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5upp ProSAT]</td></tr>

[[Category: Rustiguel, J.K]]

</table>

[[Category: ~~Pereira De Padua, R.A~~]]

== Disease ==

[[Category: ~~Nonato, M.C~~]]

[[http://www.uniprot.org/uniprot/FUMH_HUMAN FUMH_HUMAN]] Defects in FH are the cause of fumarase deficiency (FHD) [MIM:[http://omim.org/entry/606812 606812]]; also known as fumaricaciduria. FHD is characterized by progressive encephalopathy, developmental delay, hypotonia, cerebral atrophy and lactic and pyruvic acidemia.[:]<ref>PMID:9635293</ref> Defects in FH are the cause of hereditary leiomyomatosis and renal cell cancer (HLRCC) [MIM:[http://omim.org/entry/150800 150800]]. A disorder characterized by predisposition to cutaneous and uterine leiomyomas, and papillary type 2 renal cancer which occurs in about 20% of patients.<ref>PMID:11865300</ref>

[[Category: ~~Ajalla, M.A~~]]

== Function ==

[[http://www.uniprot.org/uniprot/FUMH_HUMAN FUMH_HUMAN]] Also acts as a tumor suppressor.

== References ==

__TOC__

</StructureSection>

[[Category: Fumarate hydratase]]

[[Category: Ajalla, M A]]

[[Category: Nonato, M C]]

[[Category: Padua, R A.Pereira de]]

[[Category: Rangel, V L]]

[[Category: Rustiguel, J K]]

[[Category: Fumarase]]

[[Category: Hsfh]]

[[Category: Lyase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5upp is ON HOLD  until Paper Publication
+==Crystal structure of human fumarate hydratase==
+<StructureSection load='5upp' size='340' side='right' caption='[[5upp]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-Authors: Rangel, V.L., Ajalla, M.A., Rustiguel, J.K., Pereira de Padua, R.A., Nonato, M.C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5upp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UPP FirstGlance]. <br>
-Description: Crystal structure of human fumarate hydratase
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>
-[[Category: Rangel, V.L]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5upp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5upp OCA], [http://pdbe.org/5upp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5upp RCSB], [http://www.ebi.ac.uk/pdbsum/5upp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5upp ProSAT]</span></td></tr>
-[[Category: Rustiguel, J.K]]
+</table>
-[[Category: Pereira De Padua, R.A]]
+== Disease ==
-[[Category: Nonato, M.C]]
+[[http://www.uniprot.org/uniprot/FUMH_HUMAN FUMH_HUMAN]] Defects in FH are the cause of fumarase deficiency (FHD) [MIM:[http://omim.org/entry/606812 606812]]; also known as fumaricaciduria. FHD is characterized by progressive encephalopathy, developmental delay, hypotonia, cerebral atrophy and lactic and pyruvic acidemia.[:]<ref>PMID:9635293</ref>   Defects in FH are the cause of hereditary leiomyomatosis and renal cell cancer (HLRCC) [MIM:[http://omim.org/entry/150800 150800]]. A disorder characterized by predisposition to cutaneous and uterine leiomyomas, and papillary type 2 renal cancer which occurs in about 20% of patients.<ref>PMID:11865300</ref>
-[[Category: Ajalla, M.A]]
+== Function ==
+[[http://www.uniprot.org/uniprot/FUMH_HUMAN FUMH_HUMAN]] Also acts as a tumor suppressor.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Fumarate hydratase]]
+[[Category: Ajalla, M A]]
+[[Category: Nonato, M C]]
+[[Category: Padua, R A.Pereira de]]
+[[Category: Rangel, V L]]
+[[Category: Rustiguel, J K]]
+[[Category: Fumarase]]
+[[Category: Hsfh]]
+[[Category: Lyase]]