6bf7: Difference between revisions
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==Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain== | |||
<StructureSection load='6bf7' size='340' side='right' caption='[[6bf7]], [[Resolution|resolution]] 6.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6bf7]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BF7 FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6b70|6b70]], [[6b3q|6b3q]], [[6b7y|6b7y]], [[6b7z|6b7z]], [[6bf6|6bf6]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bf7 OCA], [http://pdbe.org/6bf7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bf7 RCSB], [http://www.ebi.ac.uk/pdbsum/6bf7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bf7 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Insulysin]] | |||
[[Category: Bailey, L J]] | |||
[[Category: Carragher, B]] | [[Category: Carragher, B]] | ||
[[Category: Kossiakoff, A A]] | |||
[[Category: Liang, W G]] | |||
[[Category: Potter, S C]] | |||
[[Category: Tan, Y Z]] | |||
[[Category: Tang, W J]] | |||
[[Category: Wei, H]] | |||
[[Category: Zhang, Z]] | [[Category: Zhang, Z]] | ||
[[Category: | [[Category: Amyloid beta]] | ||
[[Category: | [[Category: Biosynthetic protein]] | ||
[[Category: | [[Category: Hydrolase-immune system complex]] | ||
[[Category: | [[Category: Ide]] | ||
Revision as of 06:19, 7 February 2018
Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain
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