5mwh: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5mwh is ~~ON HOLD~~

==Crystal structure of the human BRPF1 bromodomain in complex with BZ089==

~~Authors~~: ~~Zhu~~, J., ~~Caflisch~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[5mwh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MWH FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of the ~~human BRPF1 bromodomain in~~ complex ~~with BZ089~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=UWX:~{N}-[1,4-dimethyl-7-morpholin-4-yl-2,3-bis(oxidanylidene)quinoxalin-6-yl]-4-(2-methylpropyl)benzenesulfonamide'>UWX</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mwh OCA], [http://pdbe.org/5mwh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mwh RCSB], [http://www.ebi.ac.uk/pdbsum/5mwh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mwh ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Caflisch, A]]

[[Category: Zhu, J]]

[[Category: ~~Caflisch, A~~]]

[[Category: Dna binding protein]]

[[Category: Inhibitor]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5mwh is ON HOLD
+==Crystal structure of the human BRPF1 bromodomain in complex with BZ089==
+<StructureSection load='5mwh' size='340' side='right' caption='[[5mwh]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-Authors: Zhu, J., Caflisch, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5mwh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MWH FirstGlance]. <br>
-Description: Crystal structure of the human BRPF1 bromodomain in complex with BZ089
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=UWX:~{N}-[1,4-dimethyl-7-morpholin-4-yl-2,3-bis(oxidanylidene)quinoxalin-6-yl]-4-(2-methylpropyl)benzenesulfonamide'>UWX</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mwh OCA], [http://pdbe.org/5mwh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mwh RCSB], [http://www.ebi.ac.uk/pdbsum/5mwh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mwh ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Caflisch, A]]
 [[Category: Zhu, J]]
-[[Category: Caflisch, A]]
+[[Category: Dna binding protein]]
+[[Category: Inhibitor]]
+[[Category: Transcription]]