5vyk: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5vyk is ~~ON HOLD until Paper Publication~~

==Crystal structure of the BRS domain of BRAF in complex with the CC-SAM domain of KSR1==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5vyk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VYK OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VYK FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vyk OCA], [http://pdbe.org/5vyk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vyk RCSB], [http://www.ebi.ac.uk/pdbsum/5vyk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vyk ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/KSR1_HUMAN KSR1_HUMAN]] Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does not have kinase activity by itself.[UniProtKB:Q61097]

__TOC__

</StructureSection>

[[Category: Non-specific serine/threonine protein kinase]]

[[Category: Jin, T]]

[[Category: Kurinov, I]]

[[Category: Lavoie, H]]

[[Category: Maisonneuve, P]]

[[Category: Marullo, S A]]

[[Category: SIcheri, F]]

[[Category: Sahmi, M]]

[[Category: Therrien, M]]

[[Category: Thevakumaran, N]]

[[Category: Br]]

[[Category: Braf]]

[[Category: Cc-sam]]

[[Category: Complex]]

[[Category: Kinase]]

[[Category: Ksr1]]

[[Category: Pseudokinase]]

[[Category: Signaling protein]]

[[Category: Signaling]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5vyk is ON HOLD  until Paper Publication
+==Crystal structure of the BRS domain of BRAF in complex with the CC-SAM domain of KSR1==
+<StructureSection load='5vyk' size='340' side='right' caption='[[5vyk]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5vyk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VYK FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vyk OCA], [http://pdbe.org/5vyk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vyk RCSB], [http://www.ebi.ac.uk/pdbsum/5vyk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vyk ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KSR1_HUMAN KSR1_HUMAN]] Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does not have kinase activity by itself.[UniProtKB:Q61097]
+__TOC__
+</StructureSection>
+[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Jin, T]]
+[[Category: Kurinov, I]]
+[[Category: Lavoie, H]]
+[[Category: Maisonneuve, P]]
+[[Category: Marullo, S A]]
+[[Category: SIcheri, F]]
+[[Category: Sahmi, M]]
+[[Category: Therrien, M]]
+[[Category: Thevakumaran, N]]
+[[Category: Br]]
+[[Category: Braf]]
+[[Category: Cc-sam]]
+[[Category: Complex]]
+[[Category: Kinase]]
+[[Category: Ksr1]]
+[[Category: Pseudokinase]]
+[[Category: Signaling protein]]
+[[Category: Signaling]]