6c1v: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6c1v is ~~ON HOLD until Feb 14 2019~~

==MBD2 in complex with double-stranded DNA==

~~Authors~~: ~~Lei~~, M., ~~Tempel~~, W., ~~Arrowsmith~~, C.H.~~, Bountra, C~~.~~, Edwards, A~~.M., ~~Min, J~~., ~~Structural Genomics Consortium (SGC)~~

== Structural highlights ==

<table><tr><td colspan='2'>[[6c1v]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C1V FirstGlance]. <br>

~~Description~~: ~~MBD2 in complex with double-stranded DNA~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c1v OCA], [http://pdbe.org/6c1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c1v RCSB], [http://www.ebi.ac.uk/pdbsum/6c1v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c1v ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/MBD2_HUMAN MBD2_HUMAN]] Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.<ref>PMID:10471499</ref> <ref>PMID:10947852</ref> <ref>PMID:12665568</ref> <ref>PMID:16415179</ref> <ref>PMID:24307175</ref> <ref>PMID:9774669</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: Edwards, A M]]

[[Category: Lei, M]]

[[Category: Min, J]]

~~[[Category: Edwards, A.M]]~~

[[Category: Structural genomic]]

~~[[Category: Arrowsmith, C.H]]~~

[[Category: Structural ~~Genomics Consortium (Sgc)]]~~

~~[[Category: Lei, M]]~~

~~[[Category: Bountra, C~~]]

[[Category: Tempel, W]]

[[Category: Dna binding protein-dna complex]]

[[Category: Dna-binding]]

[[Category: Mbd]]

[[Category: Sgc]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6c1v is ON HOLD  until Feb 14 2019
+==MBD2 in complex with double-stranded DNA==
+<StructureSection load='6c1v' size='340' side='right' caption='[[6c1v]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-Authors: Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6c1v]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C1V FirstGlance]. <br>
-Description: MBD2 in complex with double-stranded DNA
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c1v OCA], [http://pdbe.org/6c1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c1v RCSB], [http://www.ebi.ac.uk/pdbsum/6c1v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c1v ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/MBD2_HUMAN MBD2_HUMAN]] Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.<ref>PMID:10471499</ref> <ref>PMID:10947852</ref> <ref>PMID:12665568</ref> <ref>PMID:16415179</ref> <ref>PMID:24307175</ref> <ref>PMID:9774669</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Edwards, A M]]
+[[Category: Lei, M]]
 [[Category: Min, J]]
-[[Category: Edwards, A.M]]
+[[Category: Structural genomic]]
-[[Category: Arrowsmith, C.H]]
-[[Category: Structural Genomics Consortium (Sgc)]]
-[[Category: Lei, M]]
-[[Category: Bountra, C]]
 [[Category: Tempel, W]]
+[[Category: Dna binding protein-dna complex]]
+[[Category: Dna-binding]]
+[[Category: Mbd]]
+[[Category: Sgc]]