6bw6: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The entry ~~6bw6~~ is ~~ON HOLD until Paper Publication~~

==Human GPT (DPAGT1) H129 variant in complex with tunicamycin==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6bw6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BW6 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BW6 FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene>, <scene name='pdbligand=TUM:TUNICAMYCIN'>TUM</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/UDP-N-acetylglucosamine--dolichyl-phosphate_N-acetylglucosaminephosphotransferase UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.15 2.7.8.15] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bw6 OCA], [http://pdbe.org/6bw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bw6 RCSB], [http://www.ebi.ac.uk/pdbsum/6bw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bw6 ProSAT]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/GPT_HUMAN GPT_HUMAN]] DPAGT1-CDG;Congenital myasthenic syndromes with glycosylation defect. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[[http://www.uniprot.org/uniprot/GPT_HUMAN GPT_HUMAN]] Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides.

__TOC__

</StructureSection>

[[Category: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase]]

[[Category: Kuk, A C.Y]]

[[Category: Lee, S Y]]

[[Category: Mashalidis, E H]]

[[Category: Yoo, J]]

[[Category: Endoplasmic reticulum]]

[[Category: N-linked glycosylation]]

[[Category: Natural product]]

[[Category: Transferase]]

[[Category: Transferase-antibiotic complex]]

[[Category: Tunicamycin]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6bw6 is ON HOLD  until Paper Publication
+==Human GPT (DPAGT1) H129 variant in complex with tunicamycin==
+<StructureSection load='6bw6' size='340' side='right' caption='[[6bw6]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6bw6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BW6 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene>, <scene name='pdbligand=TUM:TUNICAMYCIN'>TUM</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylglucosamine--dolichyl-phosphate_N-acetylglucosaminephosphotransferase UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.15 2.7.8.15] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bw6 OCA], [http://pdbe.org/6bw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bw6 RCSB], [http://www.ebi.ac.uk/pdbsum/6bw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bw6 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/GPT_HUMAN GPT_HUMAN]] DPAGT1-CDG;Congenital myasthenic syndromes with glycosylation defect. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/GPT_HUMAN GPT_HUMAN]] Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides.
+__TOC__
+</StructureSection>
+[[Category: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase]]
+[[Category: Kuk, A C.Y]]
+[[Category: Lee, S Y]]
+[[Category: Mashalidis, E H]]
+[[Category: Yoo, J]]
+[[Category: Endoplasmic reticulum]]
+[[Category: N-linked glycosylation]]
+[[Category: Natural product]]
+[[Category: Transferase]]
+[[Category: Transferase-antibiotic complex]]
+[[Category: Tunicamycin]]