5uot: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==CryoEM structure of the helical assembly of full length MxB==

~~The entry~~ 5uot is ~~ON HOLD~~ ~~until Paper Publication~~

== Structural highlights ==

~~Authors~~:

<table><tr><td colspan='2'>[[5uot]] is a 62 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UOT FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uot OCA], [http://pdbe.org/5uot PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uot RCSB], [http://www.ebi.ac.uk/pdbsum/5uot PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uot ProSAT]</span></td></tr>

~~Description~~:

</table>

[[Category: ~~Unreleased Structures~~]]

== Function ==

[[http://www.uniprot.org/uniprot/MX2_HUMAN MX2_HUMAN]] Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.<ref>PMID:15184662</ref> <ref>PMID:24048477</ref> <ref>PMID:24055605</ref> <ref>PMID:24121441</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Alvarez, F J.D]]

[[Category: Perilla, J R]]

[[Category: Schulten, K]]

[[Category: Zhang, P]]

[[Category: Antiviral protein]]

[[Category: Assembly]]

[[Category: Cryoem]]

[[Category: Dynamin]]

[[Category: Helical reconstruction]]

[[Category: Hiv-1]]

[[Category: Interferon]]

[[Category: Molecular dynamic simulation]]

[[Category: Mx2]]

[[Category: Mxb]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Large structure}}
+==CryoEM structure of the helical assembly of full length MxB==
-The entry 5uot is ON HOLD  until Paper Publication
+<StructureSection load='5uot' size='340' side='right' caption='[[5uot]], [[Resolution|resolution]] 4.60&Aring;' scene=''>
+== Structural highlights ==
-Authors:
+<table><tr><td colspan='2'>[[5uot]] is a 62 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UOT FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uot OCA], [http://pdbe.org/5uot PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uot RCSB], [http://www.ebi.ac.uk/pdbsum/5uot PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uot ProSAT]</span></td></tr>
-Description:
+</table>
-[[Category: Unreleased Structures]]
+{{Large structure}}
+== Function ==
+[[http://www.uniprot.org/uniprot/MX2_HUMAN MX2_HUMAN]] Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.<ref>PMID:15184662</ref> <ref>PMID:24048477</ref> <ref>PMID:24055605</ref> <ref>PMID:24121441</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Alvarez, F J.D]]
+[[Category: Perilla, J R]]
+[[Category: Schulten, K]]
+[[Category: Zhang, P]]
+[[Category: Antiviral protein]]
+[[Category: Assembly]]
+[[Category: Cryoem]]
+[[Category: Dynamin]]
+[[Category: Helical reconstruction]]
+[[Category: Hiv-1]]
+[[Category: Interferon]]
+[[Category: Molecular dynamic simulation]]
+[[Category: Mx2]]
+[[Category: Mxb]]