5uys: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The entry ~~5uys is ON HOLD~~ ~~until Feb 24 2019~~

==Human steroidogenic cytochrome P450 17A1 with 3alphaOH-5alpha-abiraterone analog==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5uys]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UYS OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UYS FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=8QD:(3alpha,5alpha,8alpha)-17-(pyridin-3-yl)androst-16-en-3-ol'>8QD</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uys OCA], [http://pdbe.org/5uys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uys RCSB], [http://www.ebi.ac.uk/pdbsum/5uys PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uys ProSAT]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN]] Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency;46,XY disorder of sex development due to isolated 17, 20 lyase deficiency. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[[http://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN]] Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.<ref>PMID:22266943</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Petrunak, E M]]

[[Category: Scott, E E]]

[[Category: Oxidoreductase]]

[[Category: Steroidogenic]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5uys is ON HOLD  until Feb 24 2019
+==Human steroidogenic cytochrome P450 17A1 with 3alphaOH-5alpha-abiraterone analog==
+<StructureSection load='5uys' size='340' side='right' caption='[[5uys]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5uys]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UYS FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8QD:(3alpha,5alpha,8alpha)-17-(pyridin-3-yl)androst-16-en-3-ol'>8QD</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nkv|4nkv]], [[4nkw|4nkw]], [[4nkx|4nkx]], [[4nky|4nky]], [[4nkz|4nkz]], [[3ruk|3ruk]], [[3swz|3swz]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uys OCA], [http://pdbe.org/5uys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uys RCSB], [http://www.ebi.ac.uk/pdbsum/5uys PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uys ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN]] Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency;46,XY disorder of sex development due to isolated 17, 20 lyase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN]] Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.<ref>PMID:22266943</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Petrunak, E M]]
+[[Category: Scott, E E]]
+[[Category: Oxidoreductase]]
+[[Category: Steroidogenic]]