6ava: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6ava is ~~ON HOLD until Paper Publication~~

==Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox==

~~Authors~~: ~~Gewe~~, M.M., ~~Rupert~~, P., ~~Strong~~, R.K.

== Structural highlights ==

<table><tr><td colspan='2'>[[6ava]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AVA FirstGlance]. <br>

~~Description: Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox~~

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ava FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ava OCA], [http://pdbe.org/6ava PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ava RCSB], [http://www.ebi.ac.uk/pdbsum/6ava PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ava ProSAT]</span></td></tr>

[[Category: Gewe, M.M]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CTXI1_MESEU CTXI1_MESEU]] Toxin with unknown function in healthy organisms. On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells. This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation (By similarity).

__TOC__

</StructureSection>

[[Category: Gewe, M M]]

[[Category: Rupert, P]]

[[Category: Strong, R.K]]

[[Category: Strong, R K]]

[[Category: Cystine knot]]

[[Category: Knottin]]

[[Category: Toxin]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6ava is ON HOLD  until Paper Publication
+==Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox==
+<StructureSection load='6ava' size='340' side='right' caption='[[6ava]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-Authors: Gewe, M.M., Rupert, P., Strong, R.K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ava]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AVA FirstGlance]. <br>
-Description: Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6atl|6atl]], [[6atm|6atm]], [[6atn|6atn]], [[6ats|6ats]], [[6atu|6atu]], [[6atw|6atw]], [[6aty|6aty]], [[6au7|6au7]], [[6aup|6aup]], [[6av8|6av8]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ava FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ava OCA], [http://pdbe.org/6ava PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ava RCSB], [http://www.ebi.ac.uk/pdbsum/6ava PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ava ProSAT]</span></td></tr>
-[[Category: Gewe, M.M]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CTXI1_MESEU CTXI1_MESEU]] Toxin with unknown function in healthy organisms. On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells. This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Gewe, M M]]
 [[Category: Rupert, P]]
-[[Category: Strong, R.K]]
+[[Category: Strong, R K]]
+[[Category: Cystine knot]]
+[[Category: Knottin]]
+[[Category: Toxin]]