6blh: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6blh is ~~ON HOLD~~ ~~until Paper Publication~~

==RSV G central conserved region bound to Fab CB017.5==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6blh]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BLH OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BLH FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6blh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6blh OCA], [http://pdbe.org/6blh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6blh RCSB], [http://www.ebi.ac.uk/pdbsum/6blh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6blh ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/GLYC_HRSV6 GLYC_HRSV6]] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities (By similarity). Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors.

__TOC__

</StructureSection>

[[Category: Jones, H G]]

[[Category: Langedijk, J P]]

[[Category: McLellan, J S]]

[[Category: Antibody]]

[[Category: Attachment]]

[[Category: Rsv]]

[[Category: Rsv g]]

[[Category: Viral protein]]

[[Category: Viral protein-immune system complex]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6blh is ON HOLD  until Paper Publication
+==RSV G central conserved region bound to Fab CB017.5==
+<StructureSection load='6blh' size='340' side='right' caption='[[6blh]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6blh]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BLH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BLH FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6blh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6blh OCA], [http://pdbe.org/6blh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6blh RCSB], [http://www.ebi.ac.uk/pdbsum/6blh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6blh ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/GLYC_HRSV6 GLYC_HRSV6]] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities (By similarity).  Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors.
+__TOC__
+</StructureSection>
+[[Category: Jones, H G]]
+[[Category: Langedijk, J P]]
+[[Category: McLellan, J S]]
+[[Category: Antibody]]
+[[Category: Attachment]]
+[[Category: Rsv]]
+[[Category: Rsv g]]
+[[Category: Viral protein]]
+[[Category: Viral protein-immune system complex]]