2x11: Difference between revisions

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==CRYSTAL STRUCTURE OF THE COMPLETE EPHA2 ECTODOMAIN IN COMPLEX WITH EPHRIN A5 RECEPTOR BINDING DOMAIN==
==Crystal structure of the complete EphA2 ectodomain in complex with ephrin A5 receptor binding domain==
<StructureSection load='2x11' size='340' side='right' caption='[[2x11]], [[Resolution|resolution]] 4.83&Aring;' scene=''>
<StructureSection load='2x11' size='340' side='right' caption='[[2x11]], [[Resolution|resolution]] 4.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x11 OCA], [http://pdbe.org/2x11 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x11 RCSB], [http://www.ebi.ac.uk/pdbsum/2x11 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x11 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x11 OCA], [http://pdbe.org/2x11 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x11 RCSB], [http://www.ebi.ac.uk/pdbsum/2x11 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x11 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/EFNA5_HUMAN EFNA5_HUMAN]] Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.<ref>PMID:10601038</ref> <ref>PMID:11870224</ref> 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x1/2x11_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x1/2x11_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 2x11" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2x11" style="background-color:#fffaf0;"></div>
==See Also==
*[[Ephrin|Ephrin]]
*[[Ephrin receptor|Ephrin receptor]]
== References ==
== References ==
<references/>
<references/>

Revision as of 07:00, 28 February 2018

Crystal structure of the complete EphA2 ectodomain in complex with ephrin A5 receptor binding domain

2x11, resolution 4.83Å

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