5ooh: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5ooh is ~~ON HOLD until Paper Publication~~

==Human biliverdin IX beta reductase: NADP/Erythrosin extra bluish ternary complex==

~~Authors~~: ~~Manso~~, J.A., ~~Pereira~~, P.J.B.

== Structural highlights ==

<table><tr><td colspan='2'>[[5ooh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OOH FirstGlance]. <br>

~~Description~~: ~~Human~~ biliverdin ~~IX beta reductase~~: ~~NADP~~/~~Erythrosin extra bluish ternary complex~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9ZZ:Erythrosin'>9ZZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ooh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ooh OCA], [http://pdbe.org/5ooh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ooh RCSB], [http://www.ebi.ac.uk/pdbsum/5ooh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ooh ProSAT]</span></td></tr>

[[Category: Pereira, P.J.B]]

</table>

[[Category: ~~Manso, J.A~~]]

== Function ==

[[http://www.uniprot.org/uniprot/BLVRB_HUMAN BLVRB_HUMAN]] Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.<ref>PMID:10620517</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Manso, J A]]

[[Category: Pereira, P J.B]]

[[Category: Biliverdin reductase]]

[[Category: Oxidoreductase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ooh is ON HOLD  until Paper Publication
+==Human biliverdin IX beta reductase: NADP/Erythrosin extra bluish ternary complex==
+<StructureSection load='5ooh' size='340' side='right' caption='[[5ooh]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
-Authors: Manso, J.A., Pereira, P.J.B.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ooh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OOH FirstGlance]. <br>
-Description: Human biliverdin IX beta reductase: NADP/Erythrosin extra bluish ternary complex
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9ZZ:Erythrosin'>9ZZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ooh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ooh OCA], [http://pdbe.org/5ooh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ooh RCSB], [http://www.ebi.ac.uk/pdbsum/5ooh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ooh ProSAT]</span></td></tr>
-[[Category: Pereira, P.J.B]]
+</table>
-[[Category: Manso, J.A]]
+== Function ==
+[[http://www.uniprot.org/uniprot/BLVRB_HUMAN BLVRB_HUMAN]] Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.<ref>PMID:10620517</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Manso, J A]]
+[[Category: Pereira, P J.B]]
+[[Category: Biliverdin reductase]]
+[[Category: Oxidoreductase]]