6ccf: Difference between revisions
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==Crystal Structure of the Human CAMKK1A in complex with Hesperadin== | |||
<StructureSection load='6ccf' size='340' side='right' caption='[[6ccf]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ccf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CCF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CCF FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H1N:N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE'>H1N</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr> | |||
[[ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ccf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ccf OCA], [http://pdbe.org/6ccf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ccf RCSB], [http://www.ebi.ac.uk/pdbsum/6ccf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ccf ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Counago, R | == Function == | ||
[[http://www.uniprot.org/uniprot/KKCC1_HUMAN KKCC1_HUMAN]] Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.<ref>PMID:12935886</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Calcium/calmodulin-dependent protein kinase]] | |||
[[Category: Arruda, P]] | |||
[[Category: Counago, R M]] | |||
[[Category: Drewry, D]] | [[Category: Drewry, D]] | ||
[[Category: Edwards, A | [[Category: Edwards, A M]] | ||
[[Category: | [[Category: Elkins, J M]] | ||
[[Category: Structural | [[Category: Massirer, K B]] | ||
[[Category: Santiago, A | [[Category: Ramos, P Z]] | ||
[[Category: | [[Category: Reis, C V.dos]] | ||
[[Category: Structural genomic]] | |||
[[Category: Santiago, A S]] | |||
[[Category: Silva, P N.B]] | |||
[[Category: Protein kinase domain]] | |||
[[Category: Psi-biology]] | |||
[[Category: Sgc]] | |||
[[Category: Transferase-transferase inhibitor complex]] | |||
Revision as of 05:08, 8 March 2018
Crystal Structure of the Human CAMKK1A in complex with Hesperadin
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