5me8: Difference between revisions
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==N-terminal domain of the human tumor suppressor ING5== | |||
<StructureSection load='5me8' size='340' side='right' caption='[[5me8]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5me8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ME8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ME8 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5me8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5me8 OCA], [http://pdbe.org/5me8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5me8 RCSB], [http://www.ebi.ac.uk/pdbsum/5me8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5me8 ProSAT]</span></td></tr> | ||
[[Category: Rojas, A | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/ING5_HUMAN ING5_HUMAN]] Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator.<ref>PMID:12750254</ref> <ref>PMID:16387653</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Blanco, F J]] | |||
[[Category: Buitrago, J A.R]] | |||
[[Category: Rojas, A L]] | |||
[[Category: Roversi, P]] | [[Category: Roversi, P]] | ||
[[Category: | [[Category: Asymmetric dimer]] | ||
[[Category: | [[Category: Ing5]] | ||
[[Category: Transcription]] | |||
[[Category: Tumor suppressor]] | |||
Revision as of 06:17, 14 March 2018
N-terminal domain of the human tumor suppressor ING5
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