5y7q: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5y7q is ~~ON HOLD until Paper Publication~~

==Crystal structure of Nuclease==

~~Authors~~: ~~Jin~~, H., ~~Cho~~, Y.

== Structural highlights ==

<table><tr><td colspan='2'>[[5y7q]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y7Q OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y7Q FirstGlance].

~~Description~~: Nuclease

</td></tr><tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Phosphodiesterase_I Phosphodiesterase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.1 3.1.4.1] </td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y7q OCA], [http://pdbe.org/5y7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y7q RCSB], [http://www.ebi.ac.uk/pdbsum/5y7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y7q ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/FAN1_PSEAE FAN1_PSEAE]] Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Also has endonuclease activity toward 5'-flaps (PubMed:25319828).[UniProtKB:Q9Y2M0]<ref>PMID:24981866</ref> <ref>PMID:25319828</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Phosphodiesterase I]]

[[Category: Cho, Y]]

[[Category: Jin, H]]

[[Category: ~~Cho, Y~~]]

[[Category: Hydrolase-dna complex]]

[[Category: Nuclease]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5y7q is ON HOLD  until Paper Publication
+==Crystal structure of Nuclease==
+<StructureSection load='5y7q' size='340' side='right' caption='[[5y7q]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-Authors: Jin, H., Cho, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5y7q]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y7Q FirstGlance]. <br>
-Description: Nuclease
+</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphodiesterase_I Phosphodiesterase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.1 3.1.4.1] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y7q OCA], [http://pdbe.org/5y7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y7q RCSB], [http://www.ebi.ac.uk/pdbsum/5y7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y7q ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/FAN1_PSEAE FAN1_PSEAE]] Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Also has endonuclease activity toward 5'-flaps (PubMed:25319828).[UniProtKB:Q9Y2M0]<ref>PMID:24981866</ref> <ref>PMID:25319828</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Phosphodiesterase I]]
+[[Category: Cho, Y]]
 [[Category: Jin, H]]
-[[Category: Cho, Y]]
+[[Category: Hydrolase-dna complex]]
+[[Category: Nuclease]]