6eno: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The ~~entry 6eno~~ is ~~ON HOLD~~

==Double cubane cluster oxidoreductase==

== Structural highlights ==

<table><tr><td colspan='2'>[[6eno]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ENO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ENO FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BJ8:Double+cubane+cluster'>BJ8</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eno OCA], [http://pdbe.org/6eno PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eno RCSB], [http://www.ebi.ac.uk/pdbsum/6eno PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eno ProSAT]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Chemically demanding reductive conversions in biology, such as the reduction of dinitrogen to ammonia or the Birch-type reduction of aromatic compounds, depend on Fe/S-cluster-containing ATPases. These reductions are typically catalyzed by two-component systems, in which an Fe/S-cluster-containing ATPase energizes an electron to reduce a metal site on the acceptor protein that drives the reductive reaction. Here, we show a two-component system featuring a double-cubane [Fe8S9]-cluster [{Fe4S4(SCys)3}2(mu2-S)]. The double-cubane-cluster-containing enzyme is capable of reducing small molecules, such as acetylene (C2H2), azide (N3(-)), and hydrazine (N2H4). We thus present a class of metalloenzymes akin in fold, metal clusters, and reactivity to nitrogenases.

~~Authors:~~ Jeoung, J.H., ~~Dobbek, H~~.

ATP-dependent substrate reduction at an [Fe8S9] double-cubane cluster.,Jeoung JH, Dobbek H Proc Natl Acad Sci U S A. 2018 Mar 5. pii: 1720489115. doi:, 10.1073/pnas.1720489115. PMID:29507223<ref>PMID:29507223</ref>

~~Description~~: ~~Double cubane cluster oxidoreductase~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

~~[[Category: Unreleased Structures]]~~

</div>

== References ==

__TOC__

</StructureSection>

[[Category: Dobbek, H]]

[[Category: Jeoung, J.H]]

[[Category: Jeoung, J H]]

[[Category: Acetylene reduction]]

[[Category: Double cubane cluster]]

[[Category: Iron-sulfur protein]]

[[Category: Oxidoreductase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6eno is ON HOLD
+==Double cubane cluster oxidoreductase==
+<StructureSection load='6eno' size='340' side='right' caption='[[6eno]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6eno]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ENO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ENO FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BJ8:Double+cubane+cluster'>BJ8</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eno OCA], [http://pdbe.org/6eno PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eno RCSB], [http://www.ebi.ac.uk/pdbsum/6eno PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eno ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Chemically demanding reductive conversions in biology, such as the reduction of dinitrogen to ammonia or the Birch-type reduction of aromatic compounds, depend on Fe/S-cluster-containing ATPases. These reductions are typically catalyzed by two-component systems, in which an Fe/S-cluster-containing ATPase energizes an electron to reduce a metal site on the acceptor protein that drives the reductive reaction. Here, we show a two-component system featuring a double-cubane [Fe8S9]-cluster [{Fe4S4(SCys)3}2(mu2-S)]. The double-cubane-cluster-containing enzyme is capable of reducing small molecules, such as acetylene (C2H2), azide (N3(-)), and hydrazine (N2H4). We thus present a class of metalloenzymes akin in fold, metal clusters, and reactivity to nitrogenases.
-Authors: Jeoung, J.H., Dobbek, H.
+ATP-dependent substrate reduction at an [Fe8S9] double-cubane cluster.,Jeoung JH, Dobbek H Proc Natl Acad Sci U S A. 2018 Mar 5. pii: 1720489115. doi:, 10.1073/pnas.1720489115. PMID:29507223<ref>PMID:29507223</ref>
-Description: Double cubane cluster oxidoreductase
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 6eno" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Dobbek, H]]
-[[Category: Jeoung, J.H]]
+[[Category: Jeoung, J H]]
+[[Category: Acetylene reduction]]
+[[Category: Double cubane cluster]]
+[[Category: Iron-sulfur protein]]
+[[Category: Oxidoreductase]]