1t7g

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

THEORETICAL MODEL OF SARS CORONAVIRUS PEPLOMER

spinqualitylabelsall models 1t7g Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, PDBsum, ProSAT Publication Abstract from PubMed The tertiary structures of the S1 and S2 domains of the spike protein of the coronavirus which is responsible of the severe acute respiratory syndrome (SARS) have been recently predicted. Here a molecular assembly of SARS coronavirus peplomer which accounts for the available functional data is suggested. The interaction between S1 and S2 appears to be stabilised by a large hydrophobic network of aromatic side chains present in both domains. This feature results to be common to all coronaviruses, suggesting potential targeting for drugs preventing coronavirus-related infections. Prediction of quaternary assembly of SARS coronavirus peplomer.,Bernini A, Spiga O, Ciutti A, Chiellini S, Bracci L, Yan X, Zheng B, Huang J, He ML, Song HD, Hao P, Zhao G, Niccolai N Biochem Biophys Res Commun. 2004 Dec 24;325(4):1210-4. PMID:15555555 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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