Major vault protein: Difference between revisions
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==Vault particles and MVP dynamics and localizations== | ==Vault particles and MVP dynamics and localizations== | ||
Vaults have been shown to occasionally open up into a flower-like structure with 8 petals (figure 1) [7 | Vaults have been shown to occasionally open up into a flower-like structure with 8 petals (figure 1) [7, 20], and that it is possible to exchange the particles that vaults are comprised from, MVP included. This means that the outer shell, which is mainly MVP, is not static but allows some degree of dynamics. | ||
Vaults, meaning MVP, have been shown to localize in different regions within cells. In most studies regarding its location, MVP was found within the cytosol [20,21,34]. Despite this, other groups have found MVP to interact with the [[nuclear pore complex]] (NPC) and thus speculate it to be a considerable mass found within them[]. In other studies MVP was shown to even enter the nucleus[]. | Vaults, meaning MVP, have been shown to localize in different regions within cells. In most studies regarding its location, MVP was found within the cytosol [20,21,34]. Despite this, other groups have found MVP to interact with the [[nuclear pore complex]] (NPC) and thus speculate it to be a considerable mass found within them[]. In other studies MVP was shown to even enter the nucleus[]. | ||
MVP, as part of the vault particle, was found to be highly dynamic, and also to react to several signals by translocating to a distinct cellular localization such as ruffling edges, neuritic tips and lipids rafts [14,35,99,113-115]. | MVP, as part of the vault particle, was found to be highly dynamic, and also to react to several signals by translocating to a distinct cellular localization such as ruffling edges, neuritic tips and lipids rafts [14,35,99,113-115]. | ||
