Pho4: Difference between revisions
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Phosphate system positive regulatory protein '''Pho4''' is a transcriptional activator which regulates the expression of phosphatase under conditions of phosphate starvation<ref>PMID:2220078</ref>. For details see [[Pho4 bHLH Protein]]. | Phosphate system positive regulatory protein '''Pho4''' is a transcriptional activator which regulates the expression of phosphatase under conditions of phosphate starvation<ref>PMID:2220078</ref>. For details see [[Pho4 bHLH Protein]]. | ||
*<scene name='72/725407/Cv/2'>Yeast Pho4 DNA-binding domain interactions with DNA</scene>. | *<scene name='72/725407/Cv/2'>Yeast Pho4 DNA-binding domain interactions with DNA</scene>. | ||
Its structure is a basic basic helix-loop-helix (bHLH) [1] | |||
The pho4 protein takes part in transcription of several yeast genes related to phosphate metabolism: | |||
PH05- encoding repressible acid phosphatase [2] | |||
PH08-encoding alkaline phosphatase [2] | |||
PH081-a regulatory gene [3] | |||
PH084- phosphate permease gene [4] | |||
</StructureSection> | </StructureSection> | ||
==sturcture== | |||
The structure of the Pho4 protein is a basic Helix-loop-helix(bHLH) , The linker sequence between Helix1(H1) and Helix2(H2) contains several residues: Asn, Glu, Pro and Ser[6]. The DNA binding site is a homodimer and two monomers in a left‐handed four‐helix bundle fold (identical to bHLH/Zip and bHLH proteins fold) [7]. | |||
[[loop structure]] | |||
Pho4 loops (conserved structure?) are long but compact and forms a short alpha-helical structure [5]. The PHO4 loop contains a Trp residue that faces the aromatic rings of Tyr52 and His55 of helix H2, and Pro28 of H2 and H1.an aromatic cluster forms a cap structure is observed. | |||
== 3D Structures of lactoferrin == | == 3D Structures of lactoferrin == | ||
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== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic | [[Category:Topic –Page]] | ||
Revision as of 12:13, 19 March 2018
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sturcture
The structure of the Pho4 protein is a basic Helix-loop-helix(bHLH) , The linker sequence between Helix1(H1) and Helix2(H2) contains several residues: Asn, Glu, Pro and Ser[6]. The DNA binding site is a homodimer and two monomers in a left‐handed four‐helix bundle fold (identical to bHLH/Zip and bHLH proteins fold) [7].
Pho4 bHLH Protein Pho4 loops (conserved structure?) are long but compact and forms a short alpha-helical structure [5]. The PHO4 loop contains a Trp residue that faces the aromatic rings of Tyr52 and His55 of helix H2, and Pro28 of H2 and H1.an aromatic cluster forms a cap structure is observed.
3D Structures of lactoferrin
Updated on 19-March-2018
1a0a – yPho4 DNA-binding domain + DNA - yeast
3w3x – yPho4 peptide + importin subunit b-3
References
Proteopedia Page Contributors and Editors (what is this?)
Inbar Yaffe, Michal Harel, Alexander Berchansky, Joel L. Sussman
