5z8o: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5z8o is ~~ON HOLD until Paper~~ Publication

==Structural of START superfamily protein MSMEG_0129 from Mycobacterium smegmatis==

== Structural highlights ==

<table><tr><td colspan='2'>[[5z8o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z8O FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z8o OCA], [http://pdbe.org/5z8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z8o RCSB], [http://www.ebi.ac.uk/pdbsum/5z8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z8o ProSAT]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Mycobacterium tuberculosis is a notorious pathogen that continues to threaten human health. Rv0164, an antigen of both T- and B-cells conserved across mycobacteria, and MSMEG_0129, its close homolog in Mycobacterium smegmatis, are predicted members of the START domain superfamily, but their molecular function is unknown. Here, gene knockout studies demonstrate MSMEG_0129 is essential for bacterial growth, suggesting Rv0164 may be a potential drug target. The MSMEG_0129 crystal structure determined at 1.95 A reveals a fold similar to that in polyketide aromatase/cyclases ZhuI and TcmN from Streptomyces sp. Structural comparisons and docking simulations, however, infer that MSMEG_0129 and Rv0164 are unlikely to catalyze polyketide aromatization/cyclization, but probably play an irreplaceable role during mycobacterial growth, for example in lipid transfer during cell envelope synthesis. This article is protected by copyright. All rights reserved.

~~Authors:~~ Zheng, S., Liu, W., Bi, L.

Structural and genetic analysis of START superfamily protein MSMEG_0129 from Mycobacterium smegmatis.,Zheng S, Zhou Y, Fleming J, Zhou Y, Zhang M, Li S, Li H, Sun B, Liu W, Bi L FEBS Lett. 2018 Mar 7. doi: 10.1002/1873-3468.13024. PMID:29512898<ref>PMID:29512898</ref>

~~Description: Structural~~ of ~~START superfamily protein MSMEG_0129 from Mycobacterium smegmatis~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

~~[[Category~~: ~~Unreleased Structures]]~~

</div>

~~[[Category: Zheng, S]]~~

== References ==

__TOC__

</StructureSection>

[[Category: Bi, L]]

[[Category: Liu, W]]

[[Category: Zheng, S]]

[[Category: Msmeg_0129]]

[[Category: Mycobacterium smegmati]]

[[Category: Start domain]]

[[Category: Unknown function]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5z8o is ON HOLD  until Paper Publication
+==Structural of START superfamily protein MSMEG_0129 from Mycobacterium smegmatis==
+<StructureSection load='5z8o' size='340' side='right' caption='[[5z8o]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5z8o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z8O FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z8o OCA], [http://pdbe.org/5z8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z8o RCSB], [http://www.ebi.ac.uk/pdbsum/5z8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z8o ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Mycobacterium tuberculosis is a notorious pathogen that continues to threaten human health. Rv0164, an antigen of both T- and B-cells conserved across mycobacteria, and MSMEG_0129, its close homolog in Mycobacterium smegmatis, are predicted members of the START domain superfamily, but their molecular function is unknown. Here, gene knockout studies demonstrate MSMEG_0129 is essential for bacterial growth, suggesting Rv0164 may be a potential drug target. The MSMEG_0129 crystal structure determined at 1.95 A reveals a fold similar to that in polyketide aromatase/cyclases ZhuI and TcmN from Streptomyces sp. Structural comparisons and docking simulations, however, infer that MSMEG_0129 and Rv0164 are unlikely to catalyze polyketide aromatization/cyclization, but probably play an irreplaceable role during mycobacterial growth, for example in lipid transfer during cell envelope synthesis. This article is protected by copyright. All rights reserved.
-Authors: Zheng, S., Liu, W., Bi, L.
+Structural and genetic analysis of START superfamily protein MSMEG_0129 from Mycobacterium smegmatis.,Zheng S, Zhou Y, Fleming J, Zhou Y, Zhang M, Li S, Li H, Sun B, Liu W, Bi L FEBS Lett. 2018 Mar 7. doi: 10.1002/1873-3468.13024. PMID:29512898<ref>PMID:29512898</ref>
-Description: Structural of START superfamily protein MSMEG_0129 from Mycobacterium smegmatis
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Zheng, S]]
+<div class="pdbe-citations 5z8o" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Bi, L]]
 [[Category: Liu, W]]
+[[Category: Zheng, S]]
+[[Category: Msmeg_0129]]
+[[Category: Mycobacterium smegmati]]
+[[Category: Start domain]]
+[[Category: Unknown function]]