5vay: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5vay is ~~ON HOLD until Paper Publication~~

==Bcl-2 complex with Beclin 1 T108D BH3 domain==

~~Authors~~: ~~Lee~~, E.F., ~~Smith~~, B.J., ~~Yao~~, S.~~, Fairlie, W~~.D.

== Structural highlights ==

<table><tr><td colspan='2'>[[5vay]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VAY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VAY FirstGlance]. <br>

~~Description~~: ~~Bcl~~-~~2 complex~~ with ~~Beclin~~ 1 ~~T108D BH3 domain~~

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vay OCA], [http://pdbe.org/5vay PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vay RCSB], [http://www.ebi.ac.uk/pdbsum/5vay PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vay ProSAT]</span></td></tr>

[[Category: Fairlie, W.D]]

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.

== Function ==

[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref> [[http://www.uniprot.org/uniprot/BECN1_HUMAN BECN1_HUMAN]] Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.<ref>PMID:20208530</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Fairlie, W D]]

[[Category: Lee, E F]]

[[Category: Smith, B J]]

[[Category: Yao, S]]

[[Category: ~~Lee, E.F~~]]

[[Category: Apoptosis]]

[[Category: ~~Smith, B.J~~]]

[[Category: Autophagy]]

[[Category: Bcl-2]]

[[Category: Beclin 1]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5vay is ON HOLD  until Paper Publication
+==Bcl-2 complex with Beclin 1 T108D BH3 domain==
+<StructureSection load='5vay' size='340' side='right' caption='[[5vay]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-Authors: Lee, E.F., Smith, B.J., Yao, S., Fairlie, W.D.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5vay]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VAY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VAY FirstGlance]. <br>
-Description: Bcl-2 complex with Beclin 1 T108D BH3 domain
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vax|5vax]], [[5vau|5vau]], [[5vb1|5vb1]], [[5vb4|5vb4]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vay OCA], [http://pdbe.org/5vay PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vay RCSB], [http://www.ebi.ac.uk/pdbsum/5vay PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vay ProSAT]</span></td></tr>
-[[Category: Fairlie, W.D]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
+== Function ==
+[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref>  [[http://www.uniprot.org/uniprot/BECN1_HUMAN BECN1_HUMAN]] Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.<ref>PMID:20208530</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Fairlie, W D]]
+[[Category: Lee, E F]]
+[[Category: Smith, B J]]
 [[Category: Yao, S]]
-[[Category: Lee, E.F]]
+[[Category: Apoptosis]]
-[[Category: Smith, B.J]]
+[[Category: Autophagy]]
+[[Category: Bcl-2]]
+[[Category: Beclin 1]]