Vpr protein: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Elia Shlush (talk | contribs) No edit summary |
Elia Shlush (talk | contribs) No edit summary |
||
| Line 2: | Line 2: | ||
== Function == | == Function == | ||
'''Vpr protein''' (Vpr) or '''viral protein R''' is a 96 amino acid protein which encoded by the human Immunodeficiency virus type 1 ([[HIV-1]]). Vpr has several roles in the progression of acquired immunodeficiency syndrome ( | '''Vpr protein''' (Vpr) or '''viral protein R''' is a 96 amino acid protein which encoded by the human Immunodeficiency virus type 1 ([[HIV-1]]). Vpr has several roles in the progression of acquired immunodeficiency syndrome (AIDS) disease, including regulation the HIV-1 pre-integration complex ({{Wikipedia|Pre-integration_complex}}) nuclear import and virus replication in non-dividing macrophages<ref>PMID:12614620</ref>. Moreover, Vpr prevents mitosis of dividing infect cells by blockade at G2 phase, when the viral promoter is more active, and induced apoptosis of these cells in G1 and M phase. Both the activities of cell cycle arrest and induce apoptosis has proven to be independence by mutations that can cause only one of these affects<ref>PMID:28075409</ref>. | ||
== Disease == | == Disease == | ||
HIV-1 retrovirus is the cause of AIDS disease. HIV-1 is a RNA virus which copy its genome to the host-cell genome | HIV-1 retrovirus is the cause of AIDS disease. HIV-1 is a RNA virus which copy its genome to the host-cell genome in infect cells. HIV-1 infects activated CD4 immune cells and macrophages. When the disease is expressing in carriers, the progressive depletion of CD4 T cells causes immunodeficiency. | ||
For more details about AIDS disease see {{Wikipedia|AIDS}} | |||
For details about another HIV-1 components and its replication pathway see [[HIV and accessory proteins]]. | For details about another HIV-1 components and its replication pathway see [[HIV and accessory proteins]]. | ||
