5vfe: Difference between revisions
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==Synaptotagmin 1 C2A domain, lead-bound== | |||
<StructureSection load='5vfe' size='340' side='right' caption='[[5vfe]], [[Resolution|resolution]] 1.38Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5vfe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VFE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VFE FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vff|5vff]], [[5vfg|5vfg]]</td></tr> | ||
[[Category: Taylor, A | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vfe OCA], [http://pdbe.org/5vfe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vfe RCSB], [http://www.ebi.ac.uk/pdbsum/5vfe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vfe ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[http://www.uniprot.org/uniprot/SYT1_MOUSE SYT1_MOUSE]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (PubMed:7961887). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (By similarity).[UniProtKB:P21579]<ref>PMID:7961887</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Hart, P J]] | |||
[[Category: Igumenova, T I]] | |||
[[Category: Taylor, A B]] | |||
[[Category: C2a domain]] | |||
[[Category: Metal binding protein]] | |||
Revision as of 13:45, 11 April 2018
Synaptotagmin 1 C2A domain, lead-bound
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