6cav: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6cav is ~~ON HOLD until Paper Publication~~

==Aminoglycoside Phosphotransferase (2'')-Ia in complex with GMPPNP, Magnesium, and Dibekacin==

~~Authors~~: ~~Caldwell~~, S.J., ~~Berghuis~~, A.M.

== Structural highlights ==

<table><tr><td colspan='2'>[[6cav]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CAV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CAV FirstGlance]. <br>

~~Description~~: ~~Aminoglycoside Phosphotransferase (2'')~~-~~Ia in complex with GMPPNP, Magnesium~~, and ~~Dibekacin~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=84D:Dibekacin'>84D</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cav OCA], [http://pdbe.org/6cav PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cav RCSB], [http://www.ebi.ac.uk/pdbsum/6cav PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cav ProSAT]</span></td></tr>

[[Category: Caldwell, S.J]]

</table>

[[Category: ~~Berghuis, A.M~~]]

== Function ==

[[http://www.uniprot.org/uniprot/AACA_STAAU AACA_STAAU]] Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein.

__TOC__

</StructureSection>

[[Category: Berghuis, A M]]

[[Category: Caldwell, S J]]

[[Category: Aminoglycoside]]

[[Category: Antibiotic]]

[[Category: Kinase]]

[[Category: Resistance]]

[[Category: Transferase]]

[[Category: Transferase-antibiotic complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6cav is ON HOLD  until Paper Publication
+==Aminoglycoside Phosphotransferase (2'')-Ia in complex with GMPPNP, Magnesium, and Dibekacin==
+<StructureSection load='6cav' size='340' side='right' caption='[[6cav]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-Authors: Caldwell, S.J., Berghuis, A.M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6cav]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CAV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CAV FirstGlance]. <br>
-Description: Aminoglycoside Phosphotransferase (2'')-Ia in complex with GMPPNP, Magnesium, and Dibekacin
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=84D:Dibekacin'>84D</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cav OCA], [http://pdbe.org/6cav PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cav RCSB], [http://www.ebi.ac.uk/pdbsum/6cav PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cav ProSAT]</span></td></tr>
-[[Category: Caldwell, S.J]]
+</table>
-[[Category: Berghuis, A.M]]
+== Function ==
+[[http://www.uniprot.org/uniprot/AACA_STAAU AACA_STAAU]] Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein.
+__TOC__
+</StructureSection>
+[[Category: Berghuis, A M]]
+[[Category: Caldwell, S J]]
+[[Category: Aminoglycoside]]
+[[Category: Antibiotic]]
+[[Category: Kinase]]
+[[Category: Resistance]]
+[[Category: Transferase]]
+[[Category: Transferase-antibiotic complex]]