5o6c: Difference between revisions
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==Crystal Structure of a threonine-selective RCR E3 ligase== | |||
<StructureSection load='5o6c' size='340' side='right' caption='[[5o6c]], [[Resolution|resolution]] 1.75Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5o6c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O6C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O6C FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RING-type_E3_ubiquitin_transferase RING-type E3 ubiquitin transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.27 2.3.2.27] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o6c OCA], [http://pdbe.org/5o6c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o6c RCSB], [http://www.ebi.ac.uk/pdbsum/5o6c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o6c ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/MYCB2_HUMAN MYCB2_HUMAN]] E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis.<ref>PMID:18308511</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: RING-type E3 ubiquitin transferase]] | |||
[[Category: Aalten, D van]] | |||
[[Category: Pao, K C]] | |||
[[Category: Rafie, K Z]] | |||
[[Category: Virdee, S]] | |||
[[Category: Ligase]] | |||
[[Category: Ring zinc binding threonine e3 ligase]] | |||
Revision as of 05:36, 18 April 2018
Crystal Structure of a threonine-selective RCR E3 ligase
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