5tos: Difference between revisions
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==Botrytis-induced kinase 1 (BIK1) from Arabidopsis thaliana== | |||
<StructureSection load='5tos' size='340' side='right' caption='[[5tos]], [[Resolution|resolution]] 2.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5tos]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TOS FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
[[Category: Fisher, A | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tos OCA], [http://pdbe.org/5tos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tos RCSB], [http://www.ebi.ac.uk/pdbsum/5tos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tos ProSAT]</span></td></tr> | ||
[[Category: Hurlburt, N | </table> | ||
[[Category: Lal, N | == Function == | ||
[[http://www.uniprot.org/uniprot/BIK1_ARATH BIK1_ARATH]] Plays a central role in immune responses (PubMed:20413097). Required to activate the resistance responses to necrotrophic pathogens (PubMed:16339855). Phosphorylates FLS2 and BAK1 (PubMed:20404519, PubMed:24104392). Involved in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) signaling and defense responses downstream of FLS2. Acts additively with PBL1 in PTI defenses (PubMed:20413097). Acts as positive regulator of the PAMP flg22-induced increase of cytosolic calcium. Binds directly and phosphorylates the NADPH oxidase RBOHD at specific sites in a calcium-independent manner to enhance reactive oxygen species (ROS) generation upon flg22 perception. ROS production in response to flg22 controls stomatal movement and restriction of bacterial entry into leaf tissues (PubMed:24629339). Seems not required for flg22-induced MAPK activation (Probable). Required for Pep1-induced defenses. Pep1 is an endogenous elicitor that potentiates PAMP-inducible plant responses. In association with PEPR1, acts downstream of the canonical ethylene signaling cascade to regulate ethylene responses (PubMed:23431184). Involved in ethylene signaling. Destabilizes EIN3, the key transcription activator in ethylene signaling, and represses EIN3-dependent transcription (PubMed:26021844). Acts as a negative regulator in brassinosteroid (BR) signaling. Functions in BR signaling by direct interaction with the BR receptor BRI1 cytosolic kinase domain (PubMed:23818580).<ref>PMID:16339855</ref> <ref>PMID:20404519</ref> <ref>PMID:20413097</ref> <ref>PMID:23431184</ref> <ref>PMID:23818580</ref> <ref>PMID:24104392</ref> <ref>PMID:24629339</ref> <ref>PMID:26021844</ref> <ref>PMID:22504181</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Non-specific serine/threonine protein kinase]] | |||
[[Category: Fisher, A J]] | |||
[[Category: Hurlburt, N K]] | |||
[[Category: Lal, N K]] | |||
[[Category: Bik1]] | |||
[[Category: Pamp-triggered immunity]] | |||
[[Category: Serine/threonine-protein kinase]] | |||
[[Category: Transferase]] | |||
