5wbs: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5wbs is ~~ON HOLD~~

==Crystal structure of Frizzled-7 CRD with an inhibitor peptide Fz7-21==

~~Authors~~: ~~Nile~~, A.H., ~~Mukund~~, S., ~~Hannoush, R~~.H., ~~Wang, W~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5wbs]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WBS FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of ~~Frizzlede~~-~~7 CRD~~ with ~~an inhibitor peptide Fz7~~-21

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wbs OCA], [http://pdbe.org/5wbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wbs RCSB], [http://www.ebi.ac.uk/pdbsum/5wbs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wbs ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/FZD7_HUMAN FZD7_HUMAN]] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

__TOC__

</StructureSection>

[[Category: Hannoush, R N]]

[[Category: Mukund, S]]

[[Category: Nile, A H]]

[[Category: Wang, W]]

[[Category: ~~Nile, A.H~~]]

[[Category: Dimerization]]

[[Category: ~~Hannoush, R.H~~]]

[[Category: Frizzled]]

[[Category: Inhibitor]]

[[Category: Signaling protein]]

[[Category: Wnt signaling]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5wbs is ON HOLD
+==Crystal structure of Frizzled-7 CRD with an inhibitor peptide Fz7-21==
+<StructureSection load='5wbs' size='340' side='right' caption='[[5wbs]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
-Authors: Nile, A.H., Mukund, S., Hannoush, R.H., Wang, W.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5wbs]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WBS FirstGlance]. <br>
-Description: Crystal structure of Frizzlede-7 CRD with an inhibitor peptide Fz7-21
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wbs OCA], [http://pdbe.org/5wbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wbs RCSB], [http://www.ebi.ac.uk/pdbsum/5wbs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wbs ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/FZD7_HUMAN FZD7_HUMAN]] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
+__TOC__
+</StructureSection>
+[[Category: Hannoush, R N]]
 [[Category: Mukund, S]]
+[[Category: Nile, A H]]
 [[Category: Wang, W]]
-[[Category: Nile, A.H]]
+[[Category: Dimerization]]
-[[Category: Hannoush, R.H]]
+[[Category: Frizzled]]
+[[Category: Inhibitor]]
+[[Category: Signaling protein]]
+[[Category: Wnt signaling]]