User:Mark Macbeth/Sandbox4: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Mark Macbeth (talk | contribs) No edit summary |
Mark Macbeth (talk | contribs) No edit summary |
||
| Line 8: | Line 8: | ||
The SRp20 protein has been shown to play a role in cancer progression and neurological disorders, specifically through alternative splicing. For example, SRp20 has been shown to play a role in alternative splicing of the Tau protein, an integral protein in the progression of Alzheimer’s disease<ref name="Corbo2013">PMID:23685143</ref>. SRp20 has even been found to serve as a splicing factor for its own mRNA, influencing the inclusion of exon 4<ref name="Corbo2013">PMID:23685143</ref>. Another function of SRp20 is its role in export of mRNA out of the nucleus, notably [https://en.wikipedia.org/wiki/Histone_H2A H2A histone] mRNA export<ref name="Hargous">PMID:17036044</ref>. | The SRp20 protein has been shown to play a role in cancer progression and neurological disorders, specifically through alternative splicing. For example, SRp20 has been shown to play a role in alternative splicing of the Tau protein, an integral protein in the progression of Alzheimer’s disease<ref name="Corbo2013">PMID:23685143</ref>. SRp20 has even been found to serve as a splicing factor for its own mRNA, influencing the inclusion of exon 4<ref name="Corbo2013">PMID:23685143</ref>. Another function of SRp20 is its role in export of mRNA out of the nucleus, notably [https://en.wikipedia.org/wiki/Histone_H2A H2A histone] mRNA export<ref name="Hargous">PMID:17036044</ref>. | ||
= Structure and Function = | |||
<StructureSection load='2i2y' size='400' frame='true' side='right' caption='SRp20 bound to RNA ligand (PDB entry [[2i2y]])' scene='78/782597/Rrmredgreen/2'> | <StructureSection load='2i2y' size='400' frame='true' side='right' caption='SRp20 bound to RNA ligand (PDB entry [[2i2y]])' scene='78/782597/Rrmredgreen/2'> | ||
