User:Mark Macbeth/Sandbox4: Difference between revisions
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The SRp20 protein is an alternative splicing factor found in homo sapiens as well as many other [https://en.wikipedia.org/wiki/Eukaryote eukaryotes]. It is a relatively small protein with a length of 164 amino acids and a weight of about 19kDa. In fact, it is the smallest member of the SR protein family. The protein contains two domains: a serine-arginine rich (SR) domain and a RNA-recognition domain (RRM)<ref name="Corbo2013">PMID:23685143</ref>. | The SRp20 protein is an alternative splicing factor found in homo sapiens as well as many other [https://en.wikipedia.org/wiki/Eukaryote eukaryotes]. It is a relatively small protein with a length of 164 amino acids and a weight of about 19kDa. In fact, it is the smallest member of the SR protein family. The protein contains two domains: a serine-arginine rich (SR) domain and a RNA-recognition domain (RRM)<ref name="Corbo2013">PMID:23685143</ref>. | ||
= History = | == History == | ||
Splicing is one step in the process of RNA maturation that cuts out introns and joins exons together. Both the spliceosome, a complex of snRNAs (U1, U2, etc.), and splicing factors like SRp20 interact with intron consensus sequences in the pre-mRNA to regulate this process. [https://en.wikipedia.org/wiki/Alternative_splicing Alternative splicing] allows one mRNA molecule to produce numerous proteins that perform different functions in a cell by inclusion and exclusion of RNA sequences. There are two main families of splicing factors: Serine-Arginine rich (SR) proteins and heterogeneous nuclear RiboNucleoProteins ([https://en.wikipedia.org/wiki/Heterogeneous_ribonucleoprotein_particle hnRNPs]). | Splicing is one step in the process of RNA maturation that cuts out introns and joins exons together. Both the spliceosome, a complex of snRNAs (U1, U2, etc.), and splicing factors like SRp20 interact with intron consensus sequences in the pre-mRNA to regulate this process. [https://en.wikipedia.org/wiki/Alternative_splicing Alternative splicing] allows one mRNA molecule to produce numerous proteins that perform different functions in a cell by inclusion and exclusion of RNA sequences. There are two main families of splicing factors: Serine-Arginine rich (SR) proteins and heterogeneous nuclear RiboNucleoProteins ([https://en.wikipedia.org/wiki/Heterogeneous_ribonucleoprotein_particle hnRNPs]). | ||
The SRp20 protein belongs to the SR protein family. All SR proteins are defined by a RNA-binding domain at the N-terminus and a serine-arginine rich domain at the C-terminus<ref name="Zahler">PMID:1577277</ref>. The discovery of this family started in the 1900s with the [https://en.wikipedia.org/wiki/Serine/arginine-rich_splicing_factor_1 SF2] (SRp30a) protein and has since come to include twelve proteins, all of which act as splicing factors. SRp20 was first discovered in calf thymus when it was separated with several other SR proteins based on their molecular weight<ref name="Zahler">PMID:1577277</ref>. | The SRp20 protein belongs to the SR protein family. All SR proteins are defined by a RNA-binding domain at the N-terminus and a serine-arginine rich domain at the C-terminus<ref name="Zahler">PMID:1577277</ref>. The discovery of this family started in the 1900s with the [https://en.wikipedia.org/wiki/Serine/arginine-rich_splicing_factor_1 SF2] (SRp30a) protein and has since come to include twelve proteins, all of which act as splicing factors. SRp20 was first discovered in calf thymus when it was separated with several other SR proteins based on their molecular weight<ref name="Zahler">PMID:1577277</ref>. | ||
