Sandbox GGC13: Difference between revisions
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Lactate Dehydrogenase(LDH) is a large, two domain- protein which catalyzes the conversion of pyruvate to lactate under anaerobic conditions.<ref>DOI 10.1126/science.1160809</ref> This conversion is coupled with the reduction of NAD+ to form the electron carrying NADH. Muscular LDH is involved in the Cori Cycle where it transports newly synthesized lactate to the liver. Liver LDH converts the lactate back to pyruvate in order to provide the precursor for gluconeogenesis.<ref>DOI 10.1126/science.136.3520.962</ref> | Lactate Dehydrogenase(LDH) is a large, two domain- protein which catalyzes the conversion of pyruvate to lactate under anaerobic conditions.<ref>DOI 10.1126/science.1160809</ref> This conversion is coupled with the reduction of NAD+ to form the electron carrying NADH. Muscular LDH is involved in the Cori Cycle where it transports newly synthesized lactate to the liver. Liver LDH converts the lactate back to pyruvate in order to provide the precursor for gluconeogenesis.<ref>DOI 10.1126/science.136.3520.962</ref> | ||
== Disease == | == Disease == | ||
Lactate dehydrogenase is found in its various isoenzyme forms throughout the body, including: brain, red blood cells, lungs, kidney, placenta, pancreas, muscle, and liver. It is kept at relatively low concentrations and is only utilized as a pathway under anaerobic conditions as it produces less ATP/glucose than oxidative phosphorylation. High levels of LDH are generally indicative of poor health. LDH translation is found to be overly expressed in pancreatic cancer and showed correlation with cell growth success rate. <ref>DOI 10.1126/science.1160809</ref><ref>10.1007/s13277-013-0679-1</ref> | Lactate dehydrogenase is found in its various isoenzyme forms throughout the body, including: brain, red blood cells, lungs, kidney, placenta, pancreas, muscle, and liver. It is kept at relatively low concentrations and is only utilized as a pathway under anaerobic conditions as it produces less ATP/glucose than oxidative phosphorylation. High levels of LDH are generally indicative of poor health. LDH translation is found to be overly expressed in pancreatic cancer and showed correlation with cell growth success rate. <ref>DOI 10.1126/science.1160809</ref> <ref>10.1007/s13277-013-0679-1</ref> | ||
Increased LDH levels are also associated with conditions such as Rhabdomyolysis which is characterized by the breakdown of skeletal muscle. This is due in part to LDH in red blood cells being released through hemolysis. | Increased LDH levels are also associated with conditions such as Rhabdomyolysis which is characterized by the breakdown of skeletal muscle. This is due in part to LDH in red blood cells being released through hemolysis. | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<ref>DOI 10.3390/molecules22122217</ref> | |||
<ref>DOI 10.1126/science.1160809</ref> | <ref>DOI 10.1126/science.1160809</ref> | ||
<ref>10.1007/s13277-013-0679-1</ref> | <ref>10.1007/s13277-013-0679-1</ref> | ||
