Sandbox GGC13: Difference between revisions

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The nicotinamide and adenine binding pockets work together to successfully bind NADH.  Both binding pockets implement hydrogen bonding and hydrophobic interactions with their ligand fragment.  In addition to the interactions within the binding pockets, NADH is also supported by ionic forces between arginine (R99) and the pyrophosphate groups. <ref>DOI 10.3390/molecules22122217</ref>
The nicotinamide and adenine binding pockets work together to successfully bind NADH.  Both binding pockets implement hydrogen bonding and hydrophobic interactions with their ligand fragment.  In addition to the interactions within the binding pockets, NADH is also supported by ionic forces between arginine (R99) and the pyrophosphate groups. <ref>DOI 10.3390/molecules22122217</ref>
<scene name='78/781197/Nadh/1'>Close up interactions between the NADH and adenine binding pockets and the cofactor, NADH.</scene>
<scene name='78/781197/Nadh/3'>Close up interactions between the NADH and adenine binding pockets and the cofactor, NADH.</scene>




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